Cord serum metabolic signatures of future progression to immune-mediated diseases
Summary: Previous prospective studies suggest that progression to autoimmune diseases is preceded by metabolic dysregulation, but it is not clear which metabolic changes are disease-specific and which are common across multiple immune-mediated diseases. Here we investigated metabolic profiles in cor...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223003450 |
| _version_ | 1827994166287663104 |
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| author | Tuulia Hyötyläinen Bagavathy Shanmugam Karthikeyan Tannaz Ghaffarzadegan Eric W. Triplett Matej Orešič Johnny Ludvigsson |
| author_facet | Tuulia Hyötyläinen Bagavathy Shanmugam Karthikeyan Tannaz Ghaffarzadegan Eric W. Triplett Matej Orešič Johnny Ludvigsson |
| author_sort | Tuulia Hyötyläinen |
| collection | DOAJ |
| description | Summary: Previous prospective studies suggest that progression to autoimmune diseases is preceded by metabolic dysregulation, but it is not clear which metabolic changes are disease-specific and which are common across multiple immune-mediated diseases. Here we investigated metabolic profiles in cord serum in a general population cohort (All Babies In Southeast Sweden; ABIS), comprising infants who progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 12), celiac disease (n = 28), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), and hypothyroidism (n = 6); and matched controls (n = 270). We observed elevated levels of multiple triacylglycerols (TGs) an alteration in several gut microbiota related metabolites in the autoimmune groups. The most distinct differences were observed in those infants who later developed HT. The specific similarities observed in metabolic profiles across autoimmune diseases suggest that they share specific common metabolic phenotypes at birth that contrast with those of healthy controls. |
| first_indexed | 2024-04-10T04:35:44Z |
| format | Article |
| id | doaj.art-ea84fa3ab9ed44d5b716b32b8bc8e02c |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T04:35:44Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-ea84fa3ab9ed44d5b716b32b8bc8e02c2023-03-10T04:35:49ZengElsevieriScience2589-00422023-03-01263106268Cord serum metabolic signatures of future progression to immune-mediated diseasesTuulia Hyötyläinen0Bagavathy Shanmugam Karthikeyan1Tannaz Ghaffarzadegan2Eric W. Triplett3Matej Orešič4Johnny Ludvigsson5School of Science and Technology, Örebro University, 702 81 Örebro, Sweden; Corresponding authorSchool of Science and Technology, Örebro University, 702 81 Örebro, Sweden; School of Medical Sciences, Örebro University, 702 81 Örebro, SwedenSchool of Science and Technology, Örebro University, 702 81 Örebro, SwedenDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences University of Florida, Gainesville, FL 32611-0700, USASchool of Medical Sciences, Örebro University, 702 81 Örebro, Sweden; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, FinlandCrown Princess Victoria’s Children’s Hospital and Division of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, SwedenSummary: Previous prospective studies suggest that progression to autoimmune diseases is preceded by metabolic dysregulation, but it is not clear which metabolic changes are disease-specific and which are common across multiple immune-mediated diseases. Here we investigated metabolic profiles in cord serum in a general population cohort (All Babies In Southeast Sweden; ABIS), comprising infants who progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 12), celiac disease (n = 28), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), and hypothyroidism (n = 6); and matched controls (n = 270). We observed elevated levels of multiple triacylglycerols (TGs) an alteration in several gut microbiota related metabolites in the autoimmune groups. The most distinct differences were observed in those infants who later developed HT. The specific similarities observed in metabolic profiles across autoimmune diseases suggest that they share specific common metabolic phenotypes at birth that contrast with those of healthy controls.http://www.sciencedirect.com/science/article/pii/S2589004223003450Health sciencesHuman metabolismImmunologyLipidomicsMetabolomics |
| spellingShingle | Tuulia Hyötyläinen Bagavathy Shanmugam Karthikeyan Tannaz Ghaffarzadegan Eric W. Triplett Matej Orešič Johnny Ludvigsson Cord serum metabolic signatures of future progression to immune-mediated diseases iScience Health sciences Human metabolism Immunology Lipidomics Metabolomics |
| title | Cord serum metabolic signatures of future progression to immune-mediated diseases |
| title_full | Cord serum metabolic signatures of future progression to immune-mediated diseases |
| title_fullStr | Cord serum metabolic signatures of future progression to immune-mediated diseases |
| title_full_unstemmed | Cord serum metabolic signatures of future progression to immune-mediated diseases |
| title_short | Cord serum metabolic signatures of future progression to immune-mediated diseases |
| title_sort | cord serum metabolic signatures of future progression to immune mediated diseases |
| topic | Health sciences Human metabolism Immunology Lipidomics Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223003450 |
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