Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats
The cytotoxic properties of zinc nanoparticles have been evaluated in vitro against several types of cancer. However, there is a lack of significant evidence of their activity in vivo, and a potential therapeutic application remains limited. Herein we report the effective inhibition of tumor growth...
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3457 |
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| author | Barbara Bobrowska-Korczak Paulina Gątarek Dorota Skrajnowska Wojciech Bielecki Rafal Wyrebiak Tomas Kovalczuk Robert Wrzesień Joanna Kałużna-Czaplińska |
| author_facet | Barbara Bobrowska-Korczak Paulina Gątarek Dorota Skrajnowska Wojciech Bielecki Rafal Wyrebiak Tomas Kovalczuk Robert Wrzesień Joanna Kałużna-Czaplińska |
| author_sort | Barbara Bobrowska-Korczak |
| collection | DOAJ |
| description | The cytotoxic properties of zinc nanoparticles have been evaluated in vitro against several types of cancer. However, there is a lack of significant evidence of their activity in vivo, and a potential therapeutic application remains limited. Herein we report the effective inhibition of tumor growth by zinc nanoparticles in vivo, as the effect of the dietary intervention, after the chemical induction in a rodent model of breast cancer. Biopsy images indicated grade 1 tumors with multiple inflammatory infiltrates in the group treated with zinc nanoparticles, whereas, in the other groups, a moderately differentiated grade 2 <i>adenocarcinoma</i> was identified. Moreover, after the supplementation with zinc nanoparticles, the levels of several metabolites associated with cancer metabolism, important to its survival, were found to have been altered. We also revealed that the biological activity of zinc in vivo depends on the size of applied particles, as the treatment with zinc microparticles has not had much effect on cancer progression. |
| first_indexed | 2024-03-10T14:56:25Z |
| format | Article |
| id | doaj.art-ea882139467f40e29246f1615936279a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:56:25Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ea882139467f40e29246f1615936279a2023-11-20T20:33:42ZengMDPI AGNutrients2072-66432020-11-011211345710.3390/nu12113457Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in RatsBarbara Bobrowska-Korczak0Paulina Gątarek1Dorota Skrajnowska2Wojciech Bielecki3Rafal Wyrebiak4Tomas Kovalczuk5Robert Wrzesień6Joanna Kałużna-Czaplińska7Department of Bromatology, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Stefana Banacha 1, 02-097 Warsaw, PolandDepartment of Chemistry, Institute of General and Ecological Chemistry, Lodz University of Technology, Stefana Zeromskiego 116, 90-924 Lodz, PolandDepartment of Bromatology, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Stefana Banacha 1, 02-097 Warsaw, PolandDepartment of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Live Sciences, Nowoursynowska 159c, 02-787 Warsaw, PolandDepartment of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Stefana Banacha 1, 02-097 Warsaw, PolandLECO Instrumente Plzen, Plaska 66, 323 00 Plzen, Czech RepublicCentral Laboratory of Experimental Animals, Medical University of Warsaw, Stefana Banacha 1a, 02-091 Warsaw, PolandDepartment of Chemistry, Institute of General and Ecological Chemistry, Lodz University of Technology, Stefana Zeromskiego 116, 90-924 Lodz, PolandThe cytotoxic properties of zinc nanoparticles have been evaluated in vitro against several types of cancer. However, there is a lack of significant evidence of their activity in vivo, and a potential therapeutic application remains limited. Herein we report the effective inhibition of tumor growth by zinc nanoparticles in vivo, as the effect of the dietary intervention, after the chemical induction in a rodent model of breast cancer. Biopsy images indicated grade 1 tumors with multiple inflammatory infiltrates in the group treated with zinc nanoparticles, whereas, in the other groups, a moderately differentiated grade 2 <i>adenocarcinoma</i> was identified. Moreover, after the supplementation with zinc nanoparticles, the levels of several metabolites associated with cancer metabolism, important to its survival, were found to have been altered. We also revealed that the biological activity of zinc in vivo depends on the size of applied particles, as the treatment with zinc microparticles has not had much effect on cancer progression.https://www.mdpi.com/2072-6643/12/11/3457breast cancerzinc nanoparticlesmetabolomic |
| spellingShingle | Barbara Bobrowska-Korczak Paulina Gątarek Dorota Skrajnowska Wojciech Bielecki Rafal Wyrebiak Tomas Kovalczuk Robert Wrzesień Joanna Kałużna-Czaplińska Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats Nutrients breast cancer zinc nanoparticles metabolomic |
| title | Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats |
| title_full | Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats |
| title_fullStr | Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats |
| title_full_unstemmed | Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats |
| title_short | Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats |
| title_sort | effect of zinc supplementation on the serum metabolites profile at the early stage of breast cancer in rats |
| topic | breast cancer zinc nanoparticles metabolomic |
| url | https://www.mdpi.com/2072-6643/12/11/3457 |
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