Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration
Back pain is one of the leading causes of disability worldwide and is frequently caused by degeneration of the intervertebral discs. The discs’ development, homeostasis, and degeneration are driven by a complex series of biochemical and physical extracellular matrix cues produced by and transmitted...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/6915 |
| _version_ | 1797479892213825536 |
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| author | Matthew J. Kibble Marco Domingos Judith A. Hoyland Stephen M. Richardson |
| author_facet | Matthew J. Kibble Marco Domingos Judith A. Hoyland Stephen M. Richardson |
| author_sort | Matthew J. Kibble |
| collection | DOAJ |
| description | Back pain is one of the leading causes of disability worldwide and is frequently caused by degeneration of the intervertebral discs. The discs’ development, homeostasis, and degeneration are driven by a complex series of biochemical and physical extracellular matrix cues produced by and transmitted to native cells. Thus, understanding the roles of different cues is essential for designing effective cellular and regenerative therapies. Omics technologies have helped identify many new matrix cues; however, comparatively few matrix molecules have thus far been incorporated into tissue engineered models. These include collagen type I and type II, laminins, glycosaminoglycans, and their biomimetic analogues. Modern biofabrication techniques, such as 3D bioprinting, are also enabling the spatial patterning of matrix molecules and growth factors to direct regional effects. These techniques should now be applied to biochemically, physically, and structurally relevant disc models incorporating disc and stem cells to investigate the drivers of healthy cell phenotype and differentiation. Such research will inform the development of efficacious regenerative therapies and improved clinical outcomes. |
| first_indexed | 2024-03-09T21:52:19Z |
| format | Article |
| id | doaj.art-ea8a48384b8b47b48459b9eb7b8c918e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:52:19Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ea8a48384b8b47b48459b9eb7b8c918e2023-11-23T20:04:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313691510.3390/ijms23136915Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and RegenerationMatthew J. Kibble0Marco Domingos1Judith A. Hoyland2Stephen M. Richardson3Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UKDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UKDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UKDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UKBack pain is one of the leading causes of disability worldwide and is frequently caused by degeneration of the intervertebral discs. The discs’ development, homeostasis, and degeneration are driven by a complex series of biochemical and physical extracellular matrix cues produced by and transmitted to native cells. Thus, understanding the roles of different cues is essential for designing effective cellular and regenerative therapies. Omics technologies have helped identify many new matrix cues; however, comparatively few matrix molecules have thus far been incorporated into tissue engineered models. These include collagen type I and type II, laminins, glycosaminoglycans, and their biomimetic analogues. Modern biofabrication techniques, such as 3D bioprinting, are also enabling the spatial patterning of matrix molecules and growth factors to direct regional effects. These techniques should now be applied to biochemically, physically, and structurally relevant disc models incorporating disc and stem cells to investigate the drivers of healthy cell phenotype and differentiation. Such research will inform the development of efficacious regenerative therapies and improved clinical outcomes.https://www.mdpi.com/1422-0067/23/13/6915intervertebralmatrixcuesbiomimeticlamininbioprinting |
| spellingShingle | Matthew J. Kibble Marco Domingos Judith A. Hoyland Stephen M. Richardson Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration International Journal of Molecular Sciences intervertebral matrix cues biomimetic laminin bioprinting |
| title | Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration |
| title_full | Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration |
| title_fullStr | Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration |
| title_full_unstemmed | Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration |
| title_short | Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration |
| title_sort | importance of matrix cues on intervertebral disc development degeneration and regeneration |
| topic | intervertebral matrix cues biomimetic laminin bioprinting |
| url | https://www.mdpi.com/1422-0067/23/13/6915 |
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