Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results
Background Previous studies have confirmed the higher risk of bladder cancer (BC) and rectal cancer (RC) development among prostate cancer (PCa) patients receiving radiotherapy. In this study, we intend to explore the long-term trend in second BC and RC incidence among PCa patients undergoing radiot...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-05-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748231177544 |
| _version_ | 1797688198416039936 |
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| author | JinFang Lin Xiangpeng Zhan Ru Chen Tao Chen Ming Jiang Yi Li Xiaoqiang Liu Guoxian Chen Bin Fu |
| author_facet | JinFang Lin Xiangpeng Zhan Ru Chen Tao Chen Ming Jiang Yi Li Xiaoqiang Liu Guoxian Chen Bin Fu |
| author_sort | JinFang Lin |
| collection | DOAJ |
| description | Background Previous studies have confirmed the higher risk of bladder cancer (BC) and rectal cancer (RC) development among prostate cancer (PCa) patients receiving radiotherapy. In this study, we intend to explore the long-term trend in second BC and RC incidence among PCa patients undergoing radiotherapy. Method We identified first primary PCa patients diagnosed between 1975 and 2014 from the Surveillance, Epidemiology, and End Results (SEER)-9 cancer registries. Standardized incidence ratios (SIRs) were calculated by calendar year of diagnosis among PCa patients receiving radiotherapy and not. P trends were evaluated using Poisson regression. 10-year cumulative incidence of BC and RC was calculated utilizing competing risk regression model. Result Of PCa patients treated with radiotherapy, SIRs of BC increased from .82 (95% CI: .35- 1.61) in 1980–1984 to 1.58 (95% CI: 1.48–1.68) in 2010-2014 ( Ptrend =.003). SIRs of RC increased from 1.01 (95% CI: .27-2.58) in 1980–1984 to 1.54 (95% CI: 1.31–1.81) in 2010-2014 ( Ptrend =.025). No statistically significant change in both BC and RC incidence was observed. The 10-year cumulative incidence of BC increased from 1975–1984 (.04%) to 2005–2014 (.15%) among PCa treated with radiotherapy. Simultaneously, the 10-year cumulative incidence of RC was demonstrated to range from 1975–1984 (.02%) to 2005–2014 (.11%). Conclusion we have observed an increasing trend in second BC and RC incidence in PCa patients receiving radiotherapy. There was no significant change in the incidence of second BC and RC in PCa without radiotherapy. These results reflect the increasing clinical burden of second malignant tumors in PCa patients undergoing radiotherapy. |
| first_indexed | 2024-03-12T01:27:50Z |
| format | Article |
| id | doaj.art-ea8a4ada970249b8b4e525d4b3cee109 |
| institution | Directory Open Access Journal |
| issn | 1526-2359 |
| language | English |
| last_indexed | 2024-03-12T01:27:50Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-ea8a4ada970249b8b4e525d4b3cee1092023-09-12T14:04:26ZengSAGE PublishingCancer Control1526-23592023-05-013010.1177/10732748231177544Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End ResultsJinFang LinXiangpeng ZhanRu ChenTao ChenMing JiangYi LiXiaoqiang LiuGuoxian ChenBin FuBackground Previous studies have confirmed the higher risk of bladder cancer (BC) and rectal cancer (RC) development among prostate cancer (PCa) patients receiving radiotherapy. In this study, we intend to explore the long-term trend in second BC and RC incidence among PCa patients undergoing radiotherapy. Method We identified first primary PCa patients diagnosed between 1975 and 2014 from the Surveillance, Epidemiology, and End Results (SEER)-9 cancer registries. Standardized incidence ratios (SIRs) were calculated by calendar year of diagnosis among PCa patients receiving radiotherapy and not. P trends were evaluated using Poisson regression. 10-year cumulative incidence of BC and RC was calculated utilizing competing risk regression model. Result Of PCa patients treated with radiotherapy, SIRs of BC increased from .82 (95% CI: .35- 1.61) in 1980–1984 to 1.58 (95% CI: 1.48–1.68) in 2010-2014 ( Ptrend =.003). SIRs of RC increased from 1.01 (95% CI: .27-2.58) in 1980–1984 to 1.54 (95% CI: 1.31–1.81) in 2010-2014 ( Ptrend =.025). No statistically significant change in both BC and RC incidence was observed. The 10-year cumulative incidence of BC increased from 1975–1984 (.04%) to 2005–2014 (.15%) among PCa treated with radiotherapy. Simultaneously, the 10-year cumulative incidence of RC was demonstrated to range from 1975–1984 (.02%) to 2005–2014 (.11%). Conclusion we have observed an increasing trend in second BC and RC incidence in PCa patients receiving radiotherapy. There was no significant change in the incidence of second BC and RC in PCa without radiotherapy. These results reflect the increasing clinical burden of second malignant tumors in PCa patients undergoing radiotherapy.https://doi.org/10.1177/10732748231177544 |
| spellingShingle | JinFang Lin Xiangpeng Zhan Ru Chen Tao Chen Ming Jiang Yi Li Xiaoqiang Liu Guoxian Chen Bin Fu Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results Cancer Control |
| title | Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results |
| title_full | Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results |
| title_fullStr | Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results |
| title_full_unstemmed | Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results |
| title_short | Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results |
| title_sort | increased burden of second bladder cancer and rectal cancer in prostate cancer treated with radiotherapy results from surveillance epidemiology and end results |
| url | https://doi.org/10.1177/10732748231177544 |
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