Dysregulation of Pulmonary Responses in Severe COVID-19
Patients with coronavirus disease 2019 (COVID-19) predominantly have a respiratory tract infection with various symptoms and high mortality is associated with respiratory failure second to severe disease. The risk factors leading to severe disease remain unclear. Here, we reanalyzed a published sing...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/6/957 |
| _version_ | 1797533175806689280 |
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| author | Dandan Wu Xuexian O. Yang |
| author_facet | Dandan Wu Xuexian O. Yang |
| author_sort | Dandan Wu |
| collection | DOAJ |
| description | Patients with coronavirus disease 2019 (COVID-19) predominantly have a respiratory tract infection with various symptoms and high mortality is associated with respiratory failure second to severe disease. The risk factors leading to severe disease remain unclear. Here, we reanalyzed a published single-cell RNA-Seq (scRNA-Seq) dataset and found that bronchoalveolar lavage fluid (BALF) of patients with severe disease compared to those with mild disease contained decreased TH17-type cells, decreased IFNA1-expressing cells with lower expression of toll-like receptor 7 (TLR7) and TLR8, increased IgA-expressing B cells, and increased hyperactive epithelial cells (and/or macrophages) expressing matrix metalloproteinases (MMPs), hyaluronan synthase 2 (HAS2), and plasminogen activator inhibitor-1 (PAI-1), which may together contribute to the pulmonary pathology in severe COVID-19. We propose IFN-I (and TLR7/TLR8) and PAI-1 as potential biomarkers to predict the susceptibility to severe COVID-19. |
| first_indexed | 2024-03-10T11:10:47Z |
| format | Article |
| id | doaj.art-ea8a5dabb8284e50be3989592312860a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:10:47Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ea8a5dabb8284e50be3989592312860a2023-11-21T20:48:37ZengMDPI AGViruses1999-49152021-05-0113695710.3390/v13060957Dysregulation of Pulmonary Responses in Severe COVID-19Dandan Wu0Xuexian O. Yang1Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USADepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USAPatients with coronavirus disease 2019 (COVID-19) predominantly have a respiratory tract infection with various symptoms and high mortality is associated with respiratory failure second to severe disease. The risk factors leading to severe disease remain unclear. Here, we reanalyzed a published single-cell RNA-Seq (scRNA-Seq) dataset and found that bronchoalveolar lavage fluid (BALF) of patients with severe disease compared to those with mild disease contained decreased TH17-type cells, decreased IFNA1-expressing cells with lower expression of toll-like receptor 7 (TLR7) and TLR8, increased IgA-expressing B cells, and increased hyperactive epithelial cells (and/or macrophages) expressing matrix metalloproteinases (MMPs), hyaluronan synthase 2 (HAS2), and plasminogen activator inhibitor-1 (PAI-1), which may together contribute to the pulmonary pathology in severe COVID-19. We propose IFN-I (and TLR7/TLR8) and PAI-1 as potential biomarkers to predict the susceptibility to severe COVID-19.https://www.mdpi.com/1999-4915/13/6/957COVID-19TH17IgAtype I interferonPAI-1 |
| spellingShingle | Dandan Wu Xuexian O. Yang Dysregulation of Pulmonary Responses in Severe COVID-19 Viruses COVID-19 TH17 IgA type I interferon PAI-1 |
| title | Dysregulation of Pulmonary Responses in Severe COVID-19 |
| title_full | Dysregulation of Pulmonary Responses in Severe COVID-19 |
| title_fullStr | Dysregulation of Pulmonary Responses in Severe COVID-19 |
| title_full_unstemmed | Dysregulation of Pulmonary Responses in Severe COVID-19 |
| title_short | Dysregulation of Pulmonary Responses in Severe COVID-19 |
| title_sort | dysregulation of pulmonary responses in severe covid 19 |
| topic | COVID-19 TH17 IgA type I interferon PAI-1 |
| url | https://www.mdpi.com/1999-4915/13/6/957 |
| work_keys_str_mv | AT dandanwu dysregulationofpulmonaryresponsesinseverecovid19 AT xuexianoyang dysregulationofpulmonaryresponsesinseverecovid19 |