Protective Effects of One 2,4-Dihydro-3H-Pyrazol-3-one Derivative against Posterior Capsular Opacification by Regulation of TGF-β2/SMADs and Non-SMAD Signaling, Collagen I, and Fibronectin Proteins

Protective Effects of One 2,4-Dihydro-3H-Pyrazol-3-one Derivative against Posterior Capsular Opacification by Regulation of TGF-β2/SMADs and Non-SMAD Signaling, Collagen I, and Fibronectin Proteins

Many elderly individuals frequently experience cataracts that interfere with vision. After cataract surgery, the left lens epithelial cell (LEC) exhibited fibrosis and posterior capsule opacification (PCO). Sometimes, there is a need for a second surgery; nevertheless, people try other methods, such...

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Bibliographic Details
Main Authors: Chun-Ching Shih, Chia-Yi Lee, Fung-Fuh Wong, Cheng-Hsiu Lin
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Current Issues in Molecular Biology
Subjects:
cataract
posterior capsule opacification
Sma and mad protein (SMAD)s pathway
non-SMADs pathway
transforming growth factor type β2 (TGF-β2
Online Access:https://www.mdpi.com/1467-3045/44/10/343

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