Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis
Like other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment. It encodes 28 multifunctional proteins that induce an imbalance in the metabolic and proteostatic homeostasis in infected cells. Recently,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2020.02101/full |
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| author | Mercedes Lachén-Montes Mercedes Lachén-Montes Mercedes Lachén-Montes Fernando J. Corrales Fernando J. Corrales Joaquín Fernández-Irigoyen Joaquín Fernández-Irigoyen Joaquín Fernández-Irigoyen Enrique Santamaría Enrique Santamaría Enrique Santamaría |
| author_facet | Mercedes Lachén-Montes Mercedes Lachén-Montes Mercedes Lachén-Montes Fernando J. Corrales Fernando J. Corrales Joaquín Fernández-Irigoyen Joaquín Fernández-Irigoyen Joaquín Fernández-Irigoyen Enrique Santamaría Enrique Santamaría Enrique Santamaría |
| author_sort | Mercedes Lachén-Montes |
| collection | DOAJ |
| description | Like other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment. It encodes 28 multifunctional proteins that induce an imbalance in the metabolic and proteostatic homeostasis in infected cells. Recently, proteomic approaches have allowed the evaluation of the impact of SARS-CoV-2 infection in human cells. Here, we discuss the current use of proteomics in three major application areas: (i) virus-protein interactomics, (ii) differential proteotyping to map the virus-induced changes in different cell types, and (iii) diagnostic methods for coronavirus infectious disease 2019 (COVID-19). Since the nasal cavity is one of the entry sites for SARS-CoV-2, we will also discuss the potential application of olfactory proteomics to provide novel insights into the olfactory dysfunction triggered by SARS-CoV-2 in patients with COVID-19. |
| first_indexed | 2024-12-21T18:47:30Z |
| format | Article |
| id | doaj.art-ea8ed10fc29143169387032e3b23e9bb |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-21T18:47:30Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ea8ed10fc29143169387032e3b23e9bb2022-12-21T18:53:50ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-09-011110.3389/fmicb.2020.02101569052Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory AxisMercedes Lachén-Montes0Mercedes Lachén-Montes1Mercedes Lachén-Montes2Fernando J. Corrales3Fernando J. Corrales4Joaquín Fernández-Irigoyen5Joaquín Fernández-Irigoyen6Joaquín Fernández-Irigoyen7Enrique Santamaría8Enrique Santamaría9Enrique Santamaría10Clinical Neuroproteomics Unit, Proteomics Platform, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Pamplona, SpainIdiSNA, Navarra Institute for Health Research, Pamplona, SpainProteored-Instituto de Salud Carlos III (ISCIII), Madrid, SpainProteored-Instituto de Salud Carlos III (ISCIII), Madrid, SpainProteomics Unit, National Centre for Biotechnology, Madrid, SpainClinical Neuroproteomics Unit, Proteomics Platform, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Pamplona, SpainIdiSNA, Navarra Institute for Health Research, Pamplona, SpainProteored-Instituto de Salud Carlos III (ISCIII), Madrid, SpainClinical Neuroproteomics Unit, Proteomics Platform, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Pamplona, SpainIdiSNA, Navarra Institute for Health Research, Pamplona, SpainProteored-Instituto de Salud Carlos III (ISCIII), Madrid, SpainLike other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment. It encodes 28 multifunctional proteins that induce an imbalance in the metabolic and proteostatic homeostasis in infected cells. Recently, proteomic approaches have allowed the evaluation of the impact of SARS-CoV-2 infection in human cells. Here, we discuss the current use of proteomics in three major application areas: (i) virus-protein interactomics, (ii) differential proteotyping to map the virus-induced changes in different cell types, and (iii) diagnostic methods for coronavirus infectious disease 2019 (COVID-19). Since the nasal cavity is one of the entry sites for SARS-CoV-2, we will also discuss the potential application of olfactory proteomics to provide novel insights into the olfactory dysfunction triggered by SARS-CoV-2 in patients with COVID-19.https://www.frontiersin.org/article/10.3389/fmicb.2020.02101/fullproteomicscoronavirus infectious disease 2019severe acute respiratory syndrome coronavirus-2smellmass-spectrometry |
| spellingShingle | Mercedes Lachén-Montes Mercedes Lachén-Montes Mercedes Lachén-Montes Fernando J. Corrales Fernando J. Corrales Joaquín Fernández-Irigoyen Joaquín Fernández-Irigoyen Joaquín Fernández-Irigoyen Enrique Santamaría Enrique Santamaría Enrique Santamaría Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis Frontiers in Microbiology proteomics coronavirus infectious disease 2019 severe acute respiratory syndrome coronavirus-2 smell mass-spectrometry |
| title | Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis |
| title_full | Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis |
| title_fullStr | Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis |
| title_full_unstemmed | Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis |
| title_short | Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis |
| title_sort | proteomics insights into the molecular basis of sars cov 2 infection what we can learn from the human olfactory axis |
| topic | proteomics coronavirus infectious disease 2019 severe acute respiratory syndrome coronavirus-2 smell mass-spectrometry |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2020.02101/full |
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