Common recognition topology of mex transporters of Pseudomonas aeruginosa revealed by molecular modelling

Common recognition topology of mex transporters of Pseudomonas aeruginosa revealed by molecular modelling

The secondary transporters of the resistance-nodulation-cell division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria like Pseudomonas aeruginosa. Among these RND transporters, MexB, MexF, and MexY, with partly overlapping specificities, have been implicated in pathogenicity...

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Bibliographic Details
Main Authors:	Andrea Catte, Venkata K. Ramaswamy, Attilio Vittorio Vargiu, Giuliano Malloci, Andrea Bosin, Paolo Ruggerone
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Pharmacology
Subjects:	RND efflux pumps multidrug transporter Pseudomonas aeruginosa antibiotic resistance molecular dynamics molecular modeling
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1021916/full

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