Anaplastic lymphoma kinase-positive large B-cell lymphoma: Unusual clinical and immunophenotypic features
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (ALK+ LBCL) is a rare subtype of diffuse large B-cell lymphoma. It is characterized by plasmacytic differentiation and cytoplasmic ALK positivity. Immunophenotype of ALK+ LBCL defines the terminally differentiated B-lineage cell charact...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Dermatopathology and Diagnostic Dermatology |
| Subjects: | |
| Online Access: | http://www.ijdpdd.com/article.asp?issn=2349-6029;year=2014;volume=1;issue=2;spage=75;epage=78;aulast=Galani |
| _version_ | 1819129687782195200 |
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| author | Komal S Galani Vijaya S Gadage P G Subramanian Sridhar Epari Sitaram Ghogale Sumeet Gujral |
| author_facet | Komal S Galani Vijaya S Gadage P G Subramanian Sridhar Epari Sitaram Ghogale Sumeet Gujral |
| author_sort | Komal S Galani |
| collection | DOAJ |
| description | Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (ALK+ LBCL) is a rare subtype of diffuse large B-cell lymphoma. It is characterized by plasmacytic differentiation and cytoplasmic ALK positivity. Immunophenotype of ALK+ LBCL defines the terminally differentiated B-lineage cell characterized by the absence of B-cell antigens and expression of antigen associated with plasma cell differentiation. It is characterized by an aggressive behavior and poor response to standard chemotherapy. Advanced clinical stage and extranodal disease are associated with worse survival. We present a very rare case of ALK+ LBCL in a young immunocompetent lady who presented with multiple subcutaneous nodules and discuss the role of flow cytometry for prompt and accurate confirmation of the diagnosis. |
| first_indexed | 2024-12-22T08:47:41Z |
| format | Article |
| id | doaj.art-ea921ce6f8614106a5dd82b21e71b057 |
| institution | Directory Open Access Journal |
| issn | 2349-6029 2349-6029 |
| language | English |
| last_indexed | 2024-12-22T08:47:41Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatopathology and Diagnostic Dermatology |
| spelling | doaj.art-ea921ce6f8614106a5dd82b21e71b0572022-12-21T18:32:03ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatopathology and Diagnostic Dermatology2349-60292349-60292014-01-0112757810.4103/2349-6029.147298Anaplastic lymphoma kinase-positive large B-cell lymphoma: Unusual clinical and immunophenotypic featuresKomal S GalaniVijaya S GadageP G SubramanianSridhar EpariSitaram GhogaleSumeet GujralAnaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (ALK+ LBCL) is a rare subtype of diffuse large B-cell lymphoma. It is characterized by plasmacytic differentiation and cytoplasmic ALK positivity. Immunophenotype of ALK+ LBCL defines the terminally differentiated B-lineage cell characterized by the absence of B-cell antigens and expression of antigen associated with plasma cell differentiation. It is characterized by an aggressive behavior and poor response to standard chemotherapy. Advanced clinical stage and extranodal disease are associated with worse survival. We present a very rare case of ALK+ LBCL in a young immunocompetent lady who presented with multiple subcutaneous nodules and discuss the role of flow cytometry for prompt and accurate confirmation of the diagnosis.http://www.ijdpdd.com/article.asp?issn=2349-6029;year=2014;volume=1;issue=2;spage=75;epage=78;aulast=GalaniAnaplastic lymphoma kinase positiveflow cytometrylarge B-cell lymphoma |
| spellingShingle | Komal S Galani Vijaya S Gadage P G Subramanian Sridhar Epari Sitaram Ghogale Sumeet Gujral Anaplastic lymphoma kinase-positive large B-cell lymphoma: Unusual clinical and immunophenotypic features Indian Journal of Dermatopathology and Diagnostic Dermatology Anaplastic lymphoma kinase positive flow cytometry large B-cell lymphoma |
| title | Anaplastic lymphoma kinase-positive large B-cell lymphoma: Unusual clinical and immunophenotypic features |
| title_full | Anaplastic lymphoma kinase-positive large B-cell lymphoma: Unusual clinical and immunophenotypic features |
| title_fullStr | Anaplastic lymphoma kinase-positive large B-cell lymphoma: Unusual clinical and immunophenotypic features |
| title_full_unstemmed | Anaplastic lymphoma kinase-positive large B-cell lymphoma: Unusual clinical and immunophenotypic features |
| title_short | Anaplastic lymphoma kinase-positive large B-cell lymphoma: Unusual clinical and immunophenotypic features |
| title_sort | anaplastic lymphoma kinase positive large b cell lymphoma unusual clinical and immunophenotypic features |
| topic | Anaplastic lymphoma kinase positive flow cytometry large B-cell lymphoma |
| url | http://www.ijdpdd.com/article.asp?issn=2349-6029;year=2014;volume=1;issue=2;spage=75;epage=78;aulast=Galani |
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