Effects of Functionalized Fullerenes on ROS Homeostasis Determine Their Cytoprotective or Cytotoxic Properties

Effects of Functionalized Fullerenes on ROS Homeostasis Determine Their Cytoprotective or Cytotoxic Properties

Background: Functionalized fullerenes (FF) can be considered regulators of intracellular reactive oxygen species (ROS) homeostasis; their direct oxidative damage—as well as regulation of oxidant enzymes and signaling pathways—should be considered. Methods: Uptake of two water-soluble functionalized...

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Main Authors: Svetlana V. Kostyuk, Elena V. Proskurnina, Ekaterina A. Savinova, Elizaveta S. Ershova, Olga A. Kraevaya, Larisa V. Kameneva, Pavel E. Umryukhin, Olga A. Dolgikh, Sergey I. Kutsev, Pavel A. Troshin, Natalia N. Veiko
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Nanomaterials
Subjects:
functionalized fullerenes
ROS homeostasis
oxidative stress
NOX4
ROS-signaling
oxidative DNA damage
Online Access:https://www.mdpi.com/2079-4991/10/7/1405

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