3-D nanocomposite scaffolds: Tissue engineering for bone reconstruction
A challenge to the orthopedic surgeons in veterinary and human fields is the treatment of delayed union, malunion and nonunion. Apart from renovation of arrangement and constant fixation, in many cases, adjunctive measures such as bone-grafting or the use of bone-graft substitutes, are of dominant s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2022-04-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_172917_4f767057b026dda0f18793bec49147c2.pdf |
| _version_ | 1818755375748349952 |
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| author | Saffanah Mahmood Intan Shameha Binti Abdul Razak Mohammad Yaseen Loqman Mohamed Yusof Zaid K. Jeber Fufa Gimba Md Zuki Abu Bakar Zakaria |
| author_facet | Saffanah Mahmood Intan Shameha Binti Abdul Razak Mohammad Yaseen Loqman Mohamed Yusof Zaid K. Jeber Fufa Gimba Md Zuki Abu Bakar Zakaria |
| author_sort | Saffanah Mahmood |
| collection | DOAJ |
| description | A challenge to the orthopedic surgeons in veterinary and human fields is the treatment of delayed union, malunion and nonunion. Apart from renovation of arrangement and constant fixation, in many cases, adjunctive measures such as bone-grafting or the use of bone-graft substitutes, are of dominant significance. In general bone-graft materials comprise one or more components: an osteoconductive matrix, which acts as a scaffold to new bone growth; osteoinductive proteins, backing the mitogenesis of indistinguishable cells; and osteogenic cells, which can form bone in the proper environment. Our review focuses on the currently existing bone graft and graft substitutes for the novel therapeutic approaches in the clinical situation of orthopedic surgery. This review is based on an extensive literature search of different composite scaffolds developed as bone regenerative therapies. The settlement and drawbacks of different composite scaffold developed techniques, the properties of generally used ceramics and polymers, and the properties of presently investigated synthetic composite grafts. To follow, an exhaustive review of <em>in vivo</em> models is used to test composite scaffolds in segmental bone defects (SBDs) to serve as a guide to design suitable translational studies and to recognize the challenges that require to be overcome in scaffold design for successful transformation. This includes the formative of the anatomical position within the animals, selecting the accurate study period, and an overview of scaffold presentation evaluation. |
| first_indexed | 2024-12-18T05:38:09Z |
| format | Article |
| id | doaj.art-ea93b299632e4c2fbcf0fc1d8bc36602 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-18T05:38:09Z |
| publishDate | 2022-04-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-ea93b299632e4c2fbcf0fc1d8bc366022022-12-21T21:19:15ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552022-04-0136243344410.33899/ijvs.2021.130481.18311729173-D nanocomposite scaffolds: Tissue engineering for bone reconstructionSaffanah Mahmood0Intan Shameha Binti Abdul Razak1Mohammad Yaseen2Loqman Mohamed Yusof3Zaid K. Jeber4Fufa Gimba5Md Zuki Abu Bakar Zakaria6Department of Anatomy, College of Veterinary Medicine, University of MosulDepartment of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400,Serdang, Selangor Darul Ehsan, Malaysia.Department of Electrical Engineering, College of Engineering, University of Mosul, Mosul, Iraq.Department of Companion Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400, Serdang, Selangor Darul Ehsan, Malaysia.Department of Anesthesia Technology, Al-Noor University College, Bartla, Mosul, IraqAvian influenza control project, Animal components, Taraba state ministry of Agriculture and Natural resources Jalingo, Taraba, Nigeria.Laboratory of Molecular Biomedicine, Institute of Biosciences, Universiti Putra Malaysia (UPM), 43400,Serdang, Selangor Darul Ehsan, MalaysiaA challenge to the orthopedic surgeons in veterinary and human fields is the treatment of delayed union, malunion and nonunion. Apart from renovation of arrangement and constant fixation, in many cases, adjunctive measures such as bone-grafting or the use of bone-graft substitutes, are of dominant significance. In general bone-graft materials comprise one or more components: an osteoconductive matrix, which acts as a scaffold to new bone growth; osteoinductive proteins, backing the mitogenesis of indistinguishable cells; and osteogenic cells, which can form bone in the proper environment. Our review focuses on the currently existing bone graft and graft substitutes for the novel therapeutic approaches in the clinical situation of orthopedic surgery. This review is based on an extensive literature search of different composite scaffolds developed as bone regenerative therapies. The settlement and drawbacks of different composite scaffold developed techniques, the properties of generally used ceramics and polymers, and the properties of presently investigated synthetic composite grafts. To follow, an exhaustive review of <em>in vivo</em> models is used to test composite scaffolds in segmental bone defects (SBDs) to serve as a guide to design suitable translational studies and to recognize the challenges that require to be overcome in scaffold design for successful transformation. This includes the formative of the anatomical position within the animals, selecting the accurate study period, and an overview of scaffold presentation evaluation.https://vetmedmosul.com/article_172917_4f767057b026dda0f18793bec49147c2.pdfbone engineering,,,،,؛3d scaffolds,,,،,؛bionanoceramic |
| spellingShingle | Saffanah Mahmood Intan Shameha Binti Abdul Razak Mohammad Yaseen Loqman Mohamed Yusof Zaid K. Jeber Fufa Gimba Md Zuki Abu Bakar Zakaria 3-D nanocomposite scaffolds: Tissue engineering for bone reconstruction Iraqi Journal of Veterinary Sciences bone engineering,, ,،,؛3d scaffolds,, ,،,؛bionanoceramic |
| title | 3-D nanocomposite scaffolds: Tissue engineering for bone reconstruction |
| title_full | 3-D nanocomposite scaffolds: Tissue engineering for bone reconstruction |
| title_fullStr | 3-D nanocomposite scaffolds: Tissue engineering for bone reconstruction |
| title_full_unstemmed | 3-D nanocomposite scaffolds: Tissue engineering for bone reconstruction |
| title_short | 3-D nanocomposite scaffolds: Tissue engineering for bone reconstruction |
| title_sort | 3 d nanocomposite scaffolds tissue engineering for bone reconstruction |
| topic | bone engineering,, ,،,؛3d scaffolds,, ,،,؛bionanoceramic |
| url | https://vetmedmosul.com/article_172917_4f767057b026dda0f18793bec49147c2.pdf |
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