Hypoxia-inducible factors: cancer progression and clinical translation
Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2 supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co-opt this homeostatic system to drive cancer progression. HIFs activate the transcription of thousands of genes that...
Main Authors: | Elizabeth E. Wicks, Gregg L. Semenza |
---|---|
Format: | Article |
Language: | English |
Published: |
American Society for Clinical Investigation
2022-06-01
|
Series: | The Journal of Clinical Investigation |
Online Access: | https://doi.org/10.1172/JCI159839 |
Similar Items
-
Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner.
by: Seiko Oda, et al.
Published: (2008-01-01) -
Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes
by: Yajing Lyu, et al.
Published: (2024-04-01) -
Hypoxia and hypoxia-inducible factors in leukaemias
by: Margaux eDeynoux, et al.
Published: (2016-02-01) -
Tumor hypoxia and role of hypoxia-inducible factor in oral cancer
by: Pooja Singh, et al.
Published: (2024-01-01) -
Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression
by: Kiyofumi Shimoji, et al.
Published: (2023-11-01)