Effects of Oral Exposure to Titanium Dioxide Nanoparticles on the Liver, Small Intestine, and Kidney of Rats assessed by light microscopy and Transmission Electron Microscopy
The TiO2 NPs are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries, and pharmaceutical preparations with potential risks to human health and the environment. The present study investigated the effects of different doses of TiO2 NPs on th...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ferdowsi University of Mashhad
2023-04-01
|
| Series: | The Iranian Journal of Veterinary Science and Technology |
| Subjects: | |
| Online Access: | https://ijvst.um.ac.ir/article_43705_683515612677f965389564b223f0c5f4.pdf |
| _version_ | 1797768932836245504 |
|---|---|
| author | Rahele Javaheri Ahmad Reza Raji Amir Moghaddam Jafari Hossein Nourani |
| author_facet | Rahele Javaheri Ahmad Reza Raji Amir Moghaddam Jafari Hossein Nourani |
| author_sort | Rahele Javaheri |
| collection | DOAJ |
| description | The TiO2 NPs are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries, and pharmaceutical preparations with potential risks to human health and the environment. The present study investigated the effects of different doses of TiO2 NPs on the liver, small intestine, and kidney tissues in the rat. The TiO2 NPs were administrated daily through gavage at the doses of 10, 20, and 50 mg/kg BW for 2 months. A total of 32 male rats were divided into four groups. After 60 days, rats were euthanized with CO2 gas (Code of Ethics: IR UM.REC.1400.327). Histopathological examination of the kidney, small intestine, and hepatic tissues treated with TiO2 NPs showed toxic changes compared to the control group. Histopathological examination revealed hemorrhage in the liver, swelling in the kidney glomerulus, as well as inflammation and damage to the mitochondria in enterocytes. Further evaluations are needed to understand the impact of different doses of NPs on human health. |
| first_indexed | 2024-03-12T21:01:32Z |
| format | Article |
| id | doaj.art-ea9c50dbb8444e4380b18c1396dbdb3c |
| institution | Directory Open Access Journal |
| issn | 2008-465X 2423-6306 |
| language | English |
| last_indexed | 2024-03-12T21:01:32Z |
| publishDate | 2023-04-01 |
| publisher | Ferdowsi University of Mashhad |
| record_format | Article |
| series | The Iranian Journal of Veterinary Science and Technology |
| spelling | doaj.art-ea9c50dbb8444e4380b18c1396dbdb3c2023-07-31T07:41:16ZengFerdowsi University of MashhadThe Iranian Journal of Veterinary Science and Technology2008-465X2423-63062023-04-01151414810.22067/ijvst.2023.78900.119443705Effects of Oral Exposure to Titanium Dioxide Nanoparticles on the Liver, Small Intestine, and Kidney of Rats assessed by light microscopy and Transmission Electron MicroscopyRahele Javaheri0Ahmad Reza Raji1Amir Moghaddam Jafari2Hossein Nourani3PhD student of comparative Histology, School of veterinary medicine, Ferdowsi University of Mashhad, Mashhad, IranDepartment of Basic Sciences, Faculty of Veterinary medicine, Ferdowsi University of Mashhad, Mashhad, Iran.Department of Basic Sciences, Faculty of Veterinary medicine, Ferdowsi University of Mashhad, Mashhad, Iran.Department of Pathobiology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad , Iran.The TiO2 NPs are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries, and pharmaceutical preparations with potential risks to human health and the environment. The present study investigated the effects of different doses of TiO2 NPs on the liver, small intestine, and kidney tissues in the rat. The TiO2 NPs were administrated daily through gavage at the doses of 10, 20, and 50 mg/kg BW for 2 months. A total of 32 male rats were divided into four groups. After 60 days, rats were euthanized with CO2 gas (Code of Ethics: IR UM.REC.1400.327). Histopathological examination of the kidney, small intestine, and hepatic tissues treated with TiO2 NPs showed toxic changes compared to the control group. Histopathological examination revealed hemorrhage in the liver, swelling in the kidney glomerulus, as well as inflammation and damage to the mitochondria in enterocytes. Further evaluations are needed to understand the impact of different doses of NPs on human health.https://ijvst.um.ac.ir/article_43705_683515612677f965389564b223f0c5f4.pdfsmall intestinekidneyliverrattio2 nano particles |
| spellingShingle | Rahele Javaheri Ahmad Reza Raji Amir Moghaddam Jafari Hossein Nourani Effects of Oral Exposure to Titanium Dioxide Nanoparticles on the Liver, Small Intestine, and Kidney of Rats assessed by light microscopy and Transmission Electron Microscopy The Iranian Journal of Veterinary Science and Technology small intestine kidney liver rat tio2 nano particles |
| title | Effects of Oral Exposure to Titanium Dioxide Nanoparticles on the Liver, Small Intestine, and Kidney of Rats assessed by light microscopy and Transmission Electron Microscopy |
| title_full | Effects of Oral Exposure to Titanium Dioxide Nanoparticles on the Liver, Small Intestine, and Kidney of Rats assessed by light microscopy and Transmission Electron Microscopy |
| title_fullStr | Effects of Oral Exposure to Titanium Dioxide Nanoparticles on the Liver, Small Intestine, and Kidney of Rats assessed by light microscopy and Transmission Electron Microscopy |
| title_full_unstemmed | Effects of Oral Exposure to Titanium Dioxide Nanoparticles on the Liver, Small Intestine, and Kidney of Rats assessed by light microscopy and Transmission Electron Microscopy |
| title_short | Effects of Oral Exposure to Titanium Dioxide Nanoparticles on the Liver, Small Intestine, and Kidney of Rats assessed by light microscopy and Transmission Electron Microscopy |
| title_sort | effects of oral exposure to titanium dioxide nanoparticles on the liver small intestine and kidney of rats assessed by light microscopy and transmission electron microscopy |
| topic | small intestine kidney liver rat tio2 nano particles |
| url | https://ijvst.um.ac.ir/article_43705_683515612677f965389564b223f0c5f4.pdf |
| work_keys_str_mv | AT rahelejavaheri effectsoforalexposuretotitaniumdioxidenanoparticlesontheliversmallintestineandkidneyofratsassessedbylightmicroscopyandtransmissionelectronmicroscopy AT ahmadrezaraji effectsoforalexposuretotitaniumdioxidenanoparticlesontheliversmallintestineandkidneyofratsassessedbylightmicroscopyandtransmissionelectronmicroscopy AT amirmoghaddamjafari effectsoforalexposuretotitaniumdioxidenanoparticlesontheliversmallintestineandkidneyofratsassessedbylightmicroscopyandtransmissionelectronmicroscopy AT hosseinnourani effectsoforalexposuretotitaniumdioxidenanoparticlesontheliversmallintestineandkidneyofratsassessedbylightmicroscopyandtransmissionelectronmicroscopy |