Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report
Key Clinical Message Active pemphigus vulgaris in the mother can lead to neonatal pemphigus vulgaris, which is usually self‐limiting. Systemic corticosteroids are the mainstay of managing PV during pregnancy and until the child is breastfed. Abstract Pemphigus vulgaris (PV) is a potentially life‐thr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.8343 |
| _version_ | 1797372114544623616 |
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| author | Ayush Anand Praneet Awake Anand Bhosale Rajan Bindu Anjali Kher Prasad Bhanap |
| author_facet | Ayush Anand Praneet Awake Anand Bhosale Rajan Bindu Anjali Kher Prasad Bhanap |
| author_sort | Ayush Anand |
| collection | DOAJ |
| description | Key Clinical Message Active pemphigus vulgaris in the mother can lead to neonatal pemphigus vulgaris, which is usually self‐limiting. Systemic corticosteroids are the mainstay of managing PV during pregnancy and until the child is breastfed. Abstract Pemphigus vulgaris (PV) is a potentially life‐threatening autoimmune disease characterized by bullae and erosions over the skin and mucous membrane. PV is rarely reported in pregnant women and neonates. We reported the case of a 28‐year‐old Gravida 2 Parity 2 Living 1 who developed painful blisters and erosions in the oral cavity during third trimester of pregnancy. However, the diagnosis was delayed due to late presentation. The patient presented to our hospital at 37 weeks gestation with bullae and erosions distributed all over the body. Based on clinical evaluation and histopathology reports, she was diagnosed with PV. She delivered a child via cesarean section. The child also had similar lesions and was diagnosed with neonatal PV. Maternal PV was managed with prednisolone followed by azathioprine, leading to complete remission. No active intervention was required for neonatal PV as the condition was self‐limiting. |
| first_indexed | 2024-03-08T18:31:11Z |
| format | Article |
| id | doaj.art-ea9cf6151805465f8cc78e0314a22f88 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-08T18:31:11Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-ea9cf6151805465f8cc78e0314a22f882023-12-30T04:35:09ZengWileyClinical Case Reports2050-09042023-12-011112n/an/a10.1002/ccr3.8343Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case reportAyush Anand0Praneet Awake1Anand Bhosale2Rajan Bindu3Anjali Kher4Prasad Bhanap5BP Koirala Institute of Health Sciences Dharan NepalDepartment of Dermatology, Venereology and Leprosy Symbiosis Medical College for Women, Symbiosis International (Deemed University) Pune Maharashtra IndiaDepartment of Pathology Symbiosis Medical College for Women, Symbiosis International (Deemed University) Pune Maharashtra IndiaDepartment of Pathology Symbiosis Medical College for Women, Symbiosis International (Deemed University) Pune Maharashtra IndiaDepartment of Paediatrics Symbiosis Medical College for Women, Symbiosis International (Deemed University) Pune Maharashtra IndiaDepartment of Obstetrics and Gynaecology Symbiosis Medical College for Women, Symbiosis International (Deemed University) Pune Maharashtra IndiaKey Clinical Message Active pemphigus vulgaris in the mother can lead to neonatal pemphigus vulgaris, which is usually self‐limiting. Systemic corticosteroids are the mainstay of managing PV during pregnancy and until the child is breastfed. Abstract Pemphigus vulgaris (PV) is a potentially life‐threatening autoimmune disease characterized by bullae and erosions over the skin and mucous membrane. PV is rarely reported in pregnant women and neonates. We reported the case of a 28‐year‐old Gravida 2 Parity 2 Living 1 who developed painful blisters and erosions in the oral cavity during third trimester of pregnancy. However, the diagnosis was delayed due to late presentation. The patient presented to our hospital at 37 weeks gestation with bullae and erosions distributed all over the body. Based on clinical evaluation and histopathology reports, she was diagnosed with PV. She delivered a child via cesarean section. The child also had similar lesions and was diagnosed with neonatal PV. Maternal PV was managed with prednisolone followed by azathioprine, leading to complete remission. No active intervention was required for neonatal PV as the condition was self‐limiting.https://doi.org/10.1002/ccr3.8343case reportneonatepemphiguspregnancy |
| spellingShingle | Ayush Anand Praneet Awake Anand Bhosale Rajan Bindu Anjali Kher Prasad Bhanap Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report Clinical Case Reports case report neonate pemphigus pregnancy |
| title | Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report |
| title_full | Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report |
| title_fullStr | Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report |
| title_full_unstemmed | Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report |
| title_short | Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report |
| title_sort | pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris a case report |
| topic | case report neonate pemphigus pregnancy |
| url | https://doi.org/10.1002/ccr3.8343 |
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