Obesity exacerbates postoperative cognitive dysfunction by activating the PARP1/NAD+/SIRT1 axis through oxidative stress

Obesity exacerbates postoperative cognitive dysfunction by activating the PARP1/NAD+/SIRT1 axis through oxidative stress

The purposes of this study were to explore the impact of obesity on postoperative cognitive dysfunction (POCD) and to investigate the underlying mechanism by which obesity exacerbates POCD. In this study, fifteen-month-old male C57BL/6 J mice were fed a High-fat diet for three months to establish ob...

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Bibliographic Details
Main Authors: Li Xu, Yuanyuan Ma, Yelong Ji, Yimei Ma, Ying Wang, Xining Zhao, Shengjin Ge
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Experimental Gerontology
Subjects:
Obesity
Postoperative cognitive dysfunction
Oxidative stress
PARP1
NAD+
SIRT1
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556523002413

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http://www.sciencedirect.com/science/article/pii/S0531556523002413

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