Very early remission and increased apoptosis with the use of Pentoxifylline in children with acute lymphoblastic leukemia

Very early remission and increased apoptosis with the use of Pentoxifylline in children with acute lymphoblastic leukemia

IntroductionDespite the improvement in survival in acute lymphoblastic leukemia (ALL), there are still cases with evasion of chemotherapy-induced apoptosis. The IKK/NF-κB signaling pathway contributes to antiapoptotic gene expression. Pentoxifylline (PTX) inhibits IkB phosphorylation, blocking NF-κB...

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Dettagli Bibliografici
Autori principali: Violeta Salceda-Rivera, Pablo C. Ortiz-Lazareno, Georgina Hernández-Flores, Jorge R. Vazquez-Urrutia, Jesus Meza-Arroyo, Monzerrat Pardo-Zepeda, Hugo Romo-Rubio, Cesar Barba-Barba, Fernando Sánchez-Zubieta, Carlos Alfredo Barrón-Gallardo, Oscar Gonzalez-Ramella, Alejandro Bravo-Cuellar
Natura: Articolo
Lingua:English
Pubblicazione: Frontiers Media S.A. 2024-10-01
Serie:Frontiers in Oncology
Soggetti:
MRD
ALL
clinical trials
apoptosis
Pentoxifylline
early remission
Accesso online:https://www.frontiersin.org/articles/10.3389/fonc.2024.1401262/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1401262/full

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