Very early remission and increased apoptosis with the use of Pentoxifylline in children with acute lymphoblastic leukemia

Very early remission and increased apoptosis with the use of Pentoxifylline in children with acute lymphoblastic leukemia

IntroductionDespite the improvement in survival in acute lymphoblastic leukemia (ALL), there are still cases with evasion of chemotherapy-induced apoptosis. The IKK/NF-κB signaling pathway contributes to antiapoptotic gene expression. Pentoxifylline (PTX) inhibits IkB phosphorylation, blocking NF-κB...

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Detalhes bibliográficos
Principais autores: Violeta Salceda-Rivera, Pablo C. Ortiz-Lazareno, Georgina Hernández-Flores, Jorge R. Vazquez-Urrutia, Jesus Meza-Arroyo, Monzerrat Pardo-Zepeda, Hugo Romo-Rubio, Cesar Barba-Barba, Fernando Sánchez-Zubieta, Carlos Alfredo Barrón-Gallardo, Oscar Gonzalez-Ramella, Alejandro Bravo-Cuellar
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2024-10-01
coleção:Frontiers in Oncology
Assuntos:
MRD
ALL
clinical trials
apoptosis
Pentoxifylline
early remission
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2024.1401262/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2024.1401262/full

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