Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria
Epigenetics modulates expression levels of various important genes in both prokaryotes and eukaryotes. These epigenetic traits are heritable without any change in genetic DNA sequences. DNA methylation is a universal mechanism of epigenetic regulation in all kingdoms of life. In bacteria, DNA methyl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1129437/full |
| _version_ | 1827985731111354368 |
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| author | Qun Gao Qun Gao Shuwei Lu Shuwei Lu Yuwei Wang Longgui He Longgui He Mingshu Wang Mingshu Wang Mingshu Wang Renyong Jia Renyong Jia Renyong Jia Shun Chen Shun Chen Shun Chen Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Sai Mao Sai Mao Sai Mao Xumin Ou Xumin Ou Xumin Ou Di Sun Di Sun Di Sun Bin Tian Bin Tian Bin Tian Anchun Cheng Anchun Cheng Anchun Cheng |
| author_facet | Qun Gao Qun Gao Shuwei Lu Shuwei Lu Yuwei Wang Longgui He Longgui He Mingshu Wang Mingshu Wang Mingshu Wang Renyong Jia Renyong Jia Renyong Jia Shun Chen Shun Chen Shun Chen Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Sai Mao Sai Mao Sai Mao Xumin Ou Xumin Ou Xumin Ou Di Sun Di Sun Di Sun Bin Tian Bin Tian Bin Tian Anchun Cheng Anchun Cheng Anchun Cheng |
| author_sort | Qun Gao |
| collection | DOAJ |
| description | Epigenetics modulates expression levels of various important genes in both prokaryotes and eukaryotes. These epigenetic traits are heritable without any change in genetic DNA sequences. DNA methylation is a universal mechanism of epigenetic regulation in all kingdoms of life. In bacteria, DNA methylation is the main form of epigenetic regulation and plays important roles in affecting clinically relevant phenotypes, such as virulence, host colonization, sporulation, biofilm formation et al. In this review, we survey bacterial epigenomic studies and focus on the recent developments in the structure, function, and mechanism of several highly conserved bacterial DNA methylases. These methyltransferases are relatively common in bacteria and participate in the regulation of gene expression and chromosomal DNA replication and repair control. Recent advances in sequencing techniques capable of detecting methylation signals have enabled the characterization of genome-wide epigenetic regulation. With their involvement in critical cellular processes, these highly conserved DNA methyltransferases may emerge as promising targets for developing novel epigenetic inhibitors for biomedical applications. |
| first_indexed | 2024-04-09T23:19:06Z |
| format | Article |
| id | doaj.art-eaa175ddf10648edb2c51edb344ac763 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-09T23:19:06Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-eaa175ddf10648edb2c51edb344ac7632023-03-22T04:42:47ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-03-011410.3389/fmicb.2023.11294371129437Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteriaQun Gao0Qun Gao1Shuwei Lu2Shuwei Lu3Yuwei Wang4Longgui He5Longgui He6Mingshu Wang7Mingshu Wang8Mingshu Wang9Renyong Jia10Renyong Jia11Renyong Jia12Shun Chen13Shun Chen14Shun Chen15Dekang Zhu16Dekang Zhu17Dekang Zhu18Mafeng Liu19Mafeng Liu20Mafeng Liu21Xinxin Zhao22Xinxin Zhao23Xinxin Zhao24Qiao Yang25Qiao Yang26Qiao Yang27Ying Wu28Ying Wu29Ying Wu30Shaqiu Zhang31Shaqiu Zhang32Shaqiu Zhang33Juan Huang34Juan Huang35Juan Huang36Sai Mao37Sai Mao38Sai Mao39Xumin Ou40Xumin Ou41Xumin Ou42Di Sun43Di Sun44Di Sun45Bin Tian46Bin Tian47Bin Tian48Anchun Cheng49Anchun Cheng50Anchun Cheng51Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Livestock and Poultry Provenance Disease Research in Mianyang, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEpigenetics modulates expression levels of various important genes in both prokaryotes and eukaryotes. These epigenetic traits are heritable without any change in genetic DNA sequences. DNA methylation is a universal mechanism of epigenetic regulation in all kingdoms of life. In bacteria, DNA methylation is the main form of epigenetic regulation and plays important roles in affecting clinically relevant phenotypes, such as virulence, host colonization, sporulation, biofilm formation et al. In this review, we survey bacterial epigenomic studies and focus on the recent developments in the structure, function, and mechanism of several highly conserved bacterial DNA methylases. These methyltransferases are relatively common in bacteria and participate in the regulation of gene expression and chromosomal DNA replication and repair control. Recent advances in sequencing techniques capable of detecting methylation signals have enabled the characterization of genome-wide epigenetic regulation. With their involvement in critical cellular processes, these highly conserved DNA methyltransferases may emerge as promising targets for developing novel epigenetic inhibitors for biomedical applications.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1129437/fullDNA methyltransferaseDNA methylationrestriction-modification systemsorphan methyltransferasephase variationepigenetics |
| spellingShingle | Qun Gao Qun Gao Shuwei Lu Shuwei Lu Yuwei Wang Longgui He Longgui He Mingshu Wang Mingshu Wang Mingshu Wang Renyong Jia Renyong Jia Renyong Jia Shun Chen Shun Chen Shun Chen Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Sai Mao Sai Mao Sai Mao Xumin Ou Xumin Ou Xumin Ou Di Sun Di Sun Di Sun Bin Tian Bin Tian Bin Tian Anchun Cheng Anchun Cheng Anchun Cheng Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria Frontiers in Microbiology DNA methyltransferase DNA methylation restriction-modification systems orphan methyltransferase phase variation epigenetics |
| title | Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria |
| title_full | Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria |
| title_fullStr | Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria |
| title_full_unstemmed | Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria |
| title_short | Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria |
| title_sort | bacterial dna methyltransferase a key to the epigenetic world with lessons learned from proteobacteria |
| topic | DNA methyltransferase DNA methylation restriction-modification systems orphan methyltransferase phase variation epigenetics |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1129437/full |
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