Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha
Central nervous system (CNS) involvement of Epstein-Barr virus (EBV)-associated lymphoproliferative disease is a rare and serious complication in children with leukemia. Although rituximab therapy seems to be promising in these cases, persistent hypogammaglobulinemia may appear after treatment due t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2013-03-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-43926 |
| _version_ | 1828021588652457984 |
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| author | Berna Atabay Meral Türker Can Öztürk Sümer Sütçüoğlu Haldun Öniz Esra Arun Özer |
| author_facet | Berna Atabay Meral Türker Can Öztürk Sümer Sütçüoğlu Haldun Öniz Esra Arun Özer |
| author_sort | Berna Atabay |
| collection | DOAJ |
| description | Central nervous system (CNS) involvement of Epstein-Barr virus (EBV)-associated lymphoproliferative disease is a rare and serious complication in children with leukemia. Although rituximab therapy seems to be promising in these cases, persistent hypogammaglobulinemia may appear after treatment due to complete depletion of normal B lymphocytes in the peripheral blood. Here we report isolated CNS involvement of EBV-associated lymphoproliferative disorder in a 4-year-old boy with acute leukemia. The patient was treated with rituximab and interferon alpha; however, persistent hypogammaglobulinemia developed as a complication. Given the rarity of the complication in children receiving these agents, our experience with such a case may be helpful to others. |
| first_indexed | 2024-04-10T11:56:26Z |
| format | Article |
| id | doaj.art-eaa26bb31f344a8b9c967762e0eb5b02 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:56:26Z |
| publishDate | 2013-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-eaa26bb31f344a8b9c967762e0eb5b022023-02-15T16:16:48ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632013-03-01301586210.4274/tjh.2011.0047TJH-43926Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-AlphaBerna Atabay0Meral Türker1Can Öztürk2Sümer Sütçüoğlu3Haldun Öniz4Esra Arun Özer5Tepecik Training And Research Hospital, Department Of Pediatrics Clinic, İzmir, TurkeyTepecik Training And Research Hospital, Department Of Pediatrics Clinic, İzmir, TurkeyTepecik Training And Research Hospital, Department Of Pediatrics Clinic, İzmir, TurkeyTepecik Training And Research Hospital, Department Of Pediatrics Clinic, İzmir, TurkeyTepecik Training And Research Hospital, Department Of Pediatrics Clinic, İzmir, TurkeyTepecik Training And Research Hospital, Department Of Pediatrics Clinic, İzmir, TurkeyCentral nervous system (CNS) involvement of Epstein-Barr virus (EBV)-associated lymphoproliferative disease is a rare and serious complication in children with leukemia. Although rituximab therapy seems to be promising in these cases, persistent hypogammaglobulinemia may appear after treatment due to complete depletion of normal B lymphocytes in the peripheral blood. Here we report isolated CNS involvement of EBV-associated lymphoproliferative disorder in a 4-year-old boy with acute leukemia. The patient was treated with rituximab and interferon alpha; however, persistent hypogammaglobulinemia developed as a complication. Given the rarity of the complication in children receiving these agents, our experience with such a case may be helpful to others.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-43926epstein-barr viruslymphoproliferative disorderrituximabchildrenleukemia |
| spellingShingle | Berna Atabay Meral Türker Can Öztürk Sümer Sütçüoğlu Haldun Öniz Esra Arun Özer Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha Turkish Journal of Hematology epstein-barr virus lymphoproliferative disorder rituximab children leukemia |
| title | Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha |
| title_full | Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha |
| title_fullStr | Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha |
| title_full_unstemmed | Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha |
| title_short | Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha |
| title_sort | central nervous system involvement of epstein barr virus associated lymphoproliferative disorder in a child with acute lymphoblastic leukemia successful treatment with rituximab and interferon alpha |
| topic | epstein-barr virus lymphoproliferative disorder rituximab children leukemia |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-43926 |
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