Cross-sectional study of nutritional markers in pregnancy
Objectives: To note the value of serum Vitamin B12, folic acid, and ferritin in normal and high-risk pregnancies (HRPs) in patients attending antenatal clinic at All India Institute of Medical Sciences (AIIMS). Materials and Methods: This is a cross-sectional study where a total of 282 patients atte...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=6;spage=825;epage=830;aulast=Sharma |
| _version_ | 1819293908213956608 |
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| author | Subhadra Sharma Jai Bhagwan Sharma Manisha Yadav B R Usha Sunesh Kumar A K Mukhopadhyay |
| author_facet | Subhadra Sharma Jai Bhagwan Sharma Manisha Yadav B R Usha Sunesh Kumar A K Mukhopadhyay |
| author_sort | Subhadra Sharma |
| collection | DOAJ |
| description | Objectives: To note the value of serum Vitamin B12, folic acid, and ferritin in normal and high-risk pregnancies (HRPs) in patients attending antenatal clinic at All India Institute of Medical Sciences (AIIMS). Materials and Methods: This is a cross-sectional study where a total of 282 patients attending Gynaecology Outpatient Department at AIIMS, New Delhi, India were recruited. Among the 282 subjects, 251 were pregnant, and 31 were controls. The serum was tested for serum Vitamin B12, serum folic acid, and serum ferritin levels using Beckman Coulter Access 2 immunoassay. Results: The median value of serum folic acid level in pregnant women was 12 pg/ml with range being 2–20 pg/ml in contrast to 8 pg/ml with range being 3–20 pg/ml in nonpregnant female. This difference was statistically significant. (P = 0.05). There was no significant difference in the median level of serum Vitamin B12 and serum ferritin in pregnant and nonpregnant group. Serum Vitamin B12 level was lower in the third trimester (127 pg/ml) than in first trimester (171 pg/ml) and the difference is statistically significant (P = 0.03). Serum ferritin levels were also significantly lower in the second trimester (16.4 pg/ml) than third trimester (24.55 pg/ml). Although the median serum folic acid level was lower in the first trimester (9.84 pg/ml) than in second trimester (10.8 pg/ml) and in the third trimester (13.18 pg/ml) but the difference was not statistically significant. There was no significant difference in Vitamin B12 level in HRPs (median value 134 pg/ml) as compared to low-risk pregnancies (149.5 pg/ml). Conclusion: Serum folic acid levels are significantly higher during pregnancy as compared to nonpregnant state. However, there was no significant difference in the median level of serum Vitamin B12 and serum ferritin in pregnant and nonpregnant group. Serum folic acid level and ferritin level were significantly higher in HRPs compared to low-risk pregnancies. |
| first_indexed | 2024-12-24T04:17:54Z |
| format | Article |
| id | doaj.art-eaa669b3134a4abab85e69abc8030398 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-24T04:17:54Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-eaa669b3134a4abab85e69abc80303982022-12-21T17:15:54ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102016-01-0120682583010.4103/2230-8210.192926Cross-sectional study of nutritional markers in pregnancySubhadra SharmaJai Bhagwan SharmaManisha YadavB R UshaSunesh KumarA K MukhopadhyayObjectives: To note the value of serum Vitamin B12, folic acid, and ferritin in normal and high-risk pregnancies (HRPs) in patients attending antenatal clinic at All India Institute of Medical Sciences (AIIMS). Materials and Methods: This is a cross-sectional study where a total of 282 patients attending Gynaecology Outpatient Department at AIIMS, New Delhi, India were recruited. Among the 282 subjects, 251 were pregnant, and 31 were controls. The serum was tested for serum Vitamin B12, serum folic acid, and serum ferritin levels using Beckman Coulter Access 2 immunoassay. Results: The median value of serum folic acid level in pregnant women was 12 pg/ml with range being 2–20 pg/ml in contrast to 8 pg/ml with range being 3–20 pg/ml in nonpregnant female. This difference was statistically significant. (P = 0.05). There was no significant difference in the median level of serum Vitamin B12 and serum ferritin in pregnant and nonpregnant group. Serum Vitamin B12 level was lower in the third trimester (127 pg/ml) than in first trimester (171 pg/ml) and the difference is statistically significant (P = 0.03). Serum ferritin levels were also significantly lower in the second trimester (16.4 pg/ml) than third trimester (24.55 pg/ml). Although the median serum folic acid level was lower in the first trimester (9.84 pg/ml) than in second trimester (10.8 pg/ml) and in the third trimester (13.18 pg/ml) but the difference was not statistically significant. There was no significant difference in Vitamin B12 level in HRPs (median value 134 pg/ml) as compared to low-risk pregnancies (149.5 pg/ml). Conclusion: Serum folic acid levels are significantly higher during pregnancy as compared to nonpregnant state. However, there was no significant difference in the median level of serum Vitamin B12 and serum ferritin in pregnant and nonpregnant group. Serum folic acid level and ferritin level were significantly higher in HRPs compared to low-risk pregnancies.http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=6;spage=825;epage=830;aulast=SharmaFerritinfolic acidhigh-risk pregnanciesVitamin B12 |
| spellingShingle | Subhadra Sharma Jai Bhagwan Sharma Manisha Yadav B R Usha Sunesh Kumar A K Mukhopadhyay Cross-sectional study of nutritional markers in pregnancy Indian Journal of Endocrinology and Metabolism Ferritin folic acid high-risk pregnancies Vitamin B12 |
| title | Cross-sectional study of nutritional markers in pregnancy |
| title_full | Cross-sectional study of nutritional markers in pregnancy |
| title_fullStr | Cross-sectional study of nutritional markers in pregnancy |
| title_full_unstemmed | Cross-sectional study of nutritional markers in pregnancy |
| title_short | Cross-sectional study of nutritional markers in pregnancy |
| title_sort | cross sectional study of nutritional markers in pregnancy |
| topic | Ferritin folic acid high-risk pregnancies Vitamin B12 |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=6;spage=825;epage=830;aulast=Sharma |
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