Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis
<i>Background and Objectives</i>: Diabetes can cause various vascular complications. The Compounded Danshen-Dripping-Pill (CDDP) is widely used in China. This study aimed to analyze the effectiveness and safety of CDDP in the blood viscosity (BV) with type 2 diabetes mellitus (T2DM). <...
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MDPI AG
2023-09-01
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| Online Access: | https://www.mdpi.com/1648-9144/59/10/1730 |
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| author | Minji Wi Yumin Kim Cheol-Hyun Kim Sangkwan Lee Gi-Sang Bae Jungtae Leem Hongmin Chu |
| author_facet | Minji Wi Yumin Kim Cheol-Hyun Kim Sangkwan Lee Gi-Sang Bae Jungtae Leem Hongmin Chu |
| author_sort | Minji Wi |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Diabetes can cause various vascular complications. The Compounded Danshen-Dripping-Pill (CDDP) is widely used in China. This study aimed to analyze the effectiveness and safety of CDDP in the blood viscosity (BV) with type 2 diabetes mellitus (T2DM). <i>Materials and Methods</i>: We conducted a systematic search of seven databases from their inception to July 2022 for randomized controlled trials that used CDDP to treat T2DM. To evaluate BV, we measured low shear rate (LSR), high shear rate (HSR), and plasma viscosity (PV). Homocysteine and adiponectin levels were also assessed as factors that could affect BV. <i>Results</i>: We included 18 studies and 1532 patients with T2DM. Meta-analysis revealed that CDDP significantly reduced LSR (mean difference [MD] −2.74, 95% confidence interval [CI] −3.77 to −1.72), HSR (MD −0.86, 95% CI −1.08 to −0.63), and PV (MD −0.37, 95% CI −0.54 to −0.19) compared to controls. CDDP also reduced homocysteine (MD −8.32, 95% CI −9.05 to −7.58), and increased plasma adiponectin (MD 2.72, 95% CI 2.13 to 3.32). Adverse events were reported less frequently in the treatment groups than in controls. <i>Conclusions</i>: CDDP is effective in reducing BV on T2DM. However, due to the poor design and quality of the included studies, high-quality, well-designed studies are required in the future. |
| first_indexed | 2024-03-10T21:05:16Z |
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| language | English |
| last_indexed | 2024-03-10T21:05:16Z |
| publishDate | 2023-09-01 |
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| series | Medicina |
| spelling | doaj.art-eaa698bf8ae64e77838135616a35c3092023-11-19T17:16:20ZengMDPI AGMedicina1010-660X1648-91442023-09-015910173010.3390/medicina59101730Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-AnalysisMinji Wi0Yumin Kim1Cheol-Hyun Kim2Sangkwan Lee3Gi-Sang Bae4Jungtae Leem5Hongmin Chu6College of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of KoreaCollege of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of KoreaDepartment of Internal Medicine and Neuroscience, College of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of KoreaDepartment of Internal Medicine and Neuroscience, College of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of KoreaDepartment of Pharmacology, School of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of KoreaCollege of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of KoreaDepartment of Internal Medicine and Neuroscience, College of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of Korea<i>Background and Objectives</i>: Diabetes can cause various vascular complications. The Compounded Danshen-Dripping-Pill (CDDP) is widely used in China. This study aimed to analyze the effectiveness and safety of CDDP in the blood viscosity (BV) with type 2 diabetes mellitus (T2DM). <i>Materials and Methods</i>: We conducted a systematic search of seven databases from their inception to July 2022 for randomized controlled trials that used CDDP to treat T2DM. To evaluate BV, we measured low shear rate (LSR), high shear rate (HSR), and plasma viscosity (PV). Homocysteine and adiponectin levels were also assessed as factors that could affect BV. <i>Results</i>: We included 18 studies and 1532 patients with T2DM. Meta-analysis revealed that CDDP significantly reduced LSR (mean difference [MD] −2.74, 95% confidence interval [CI] −3.77 to −1.72), HSR (MD −0.86, 95% CI −1.08 to −0.63), and PV (MD −0.37, 95% CI −0.54 to −0.19) compared to controls. CDDP also reduced homocysteine (MD −8.32, 95% CI −9.05 to −7.58), and increased plasma adiponectin (MD 2.72, 95% CI 2.13 to 3.32). Adverse events were reported less frequently in the treatment groups than in controls. <i>Conclusions</i>: CDDP is effective in reducing BV on T2DM. However, due to the poor design and quality of the included studies, high-quality, well-designed studies are required in the future.https://www.mdpi.com/1648-9144/59/10/1730systematic reviewmeta-analysistype 2 diabetes mellitusFufang danshen dripping pillblood viscosity |
| spellingShingle | Minji Wi Yumin Kim Cheol-Hyun Kim Sangkwan Lee Gi-Sang Bae Jungtae Leem Hongmin Chu Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis Medicina systematic review meta-analysis type 2 diabetes mellitus Fufang danshen dripping pill blood viscosity |
| title | Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis |
| title_full | Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis |
| title_fullStr | Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis |
| title_short | Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis |
| title_sort | effectiveness and safety of fufang danshen dripping pill cardiotonic pill on blood viscosity and hemorheological factors for cardiovascular event prevention in patients with type 2 diabetes mellitus systematic review and meta analysis |
| topic | systematic review meta-analysis type 2 diabetes mellitus Fufang danshen dripping pill blood viscosity |
| url | https://www.mdpi.com/1648-9144/59/10/1730 |
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