Advance on Nattokinase Microbial Production and Physiological Function
With the improvement of people’s living standard, the number of patients with thromboembolism is increasing gradually. Among the existing thrombotic drugs, nattokinase attracts great attention due to its advantages of long half-life, strong specificity, small side effects, and can be taken orally di...
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| Format: | Article |
| Language: | zho |
| Published: |
The editorial department of Science and Technology of Food Industry
2022-07-01
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| Series: | Shipin gongye ke-ji |
| Subjects: | |
| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021070016 |
| _version_ | 1811224409160024064 |
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| author | Mingjing YAO Yang YANG Jing FAN Xiangying ZHAO Likun REN Xin BIAN Tonglin XING Pengyu ZHU Zhihui SUN Na ZHANG |
| author_facet | Mingjing YAO Yang YANG Jing FAN Xiangying ZHAO Likun REN Xin BIAN Tonglin XING Pengyu ZHU Zhihui SUN Na ZHANG |
| author_sort | Mingjing YAO |
| collection | DOAJ |
| description | With the improvement of people’s living standard, the number of patients with thromboembolism is increasing gradually. Among the existing thrombotic drugs, nattokinase attracts great attention due to its advantages of long half-life, strong specificity, small side effects, and can be taken orally directly. Based on the related research results at home and abroad, the structure features of nattokinase, the fibrinolytic activity and the mechanism of action of antithrombotic activity of NK are described. Also, the hard work in strain breeding, strain transformation for higher enzyme yield or better enzyme character and medium optimization are also summarized. Moreover, the physiological function of nattokinase are expounded. Finally, the challenges and future development trends of nattokinase application are prospected in order to provide theoretical basis for further research on nattokinase. |
| first_indexed | 2024-04-12T08:48:53Z |
| format | Article |
| id | doaj.art-eaa79c48e4cc4bfc907bf692e676cdb4 |
| institution | Directory Open Access Journal |
| issn | 1002-0306 |
| language | zho |
| last_indexed | 2024-04-12T08:48:53Z |
| publishDate | 2022-07-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj.art-eaa79c48e4cc4bfc907bf692e676cdb42022-12-22T03:39:38ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062022-07-01431443544410.13386/j.issn1002-0306.20210700162021070016-14Advance on Nattokinase Microbial Production and Physiological FunctionMingjing YAO0Yang YANG1Jing FAN2Xiangying ZHAO3Likun REN4Xin BIAN5Tonglin XING6Pengyu ZHU7Zhihui SUN8Na ZHANG9Key Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaKey Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaKey Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaShandong Provincial Key Laboratory of Food and Fermentation Engineering, Shandong Food Ferment Industry Research & Design Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250013, ChinaKey Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaKey Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaKey Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaKey Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaKey Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaKey Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, ChinaWith the improvement of people’s living standard, the number of patients with thromboembolism is increasing gradually. Among the existing thrombotic drugs, nattokinase attracts great attention due to its advantages of long half-life, strong specificity, small side effects, and can be taken orally directly. Based on the related research results at home and abroad, the structure features of nattokinase, the fibrinolytic activity and the mechanism of action of antithrombotic activity of NK are described. Also, the hard work in strain breeding, strain transformation for higher enzyme yield or better enzyme character and medium optimization are also summarized. Moreover, the physiological function of nattokinase are expounded. Finally, the challenges and future development trends of nattokinase application are prospected in order to provide theoretical basis for further research on nattokinase.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021070016nattokinasebacillus subtilis (natto)production by microbial fermentationphysiological function |
| spellingShingle | Mingjing YAO Yang YANG Jing FAN Xiangying ZHAO Likun REN Xin BIAN Tonglin XING Pengyu ZHU Zhihui SUN Na ZHANG Advance on Nattokinase Microbial Production and Physiological Function Shipin gongye ke-ji nattokinase bacillus subtilis (natto) production by microbial fermentation physiological function |
| title | Advance on Nattokinase Microbial Production and Physiological Function |
| title_full | Advance on Nattokinase Microbial Production and Physiological Function |
| title_fullStr | Advance on Nattokinase Microbial Production and Physiological Function |
| title_full_unstemmed | Advance on Nattokinase Microbial Production and Physiological Function |
| title_short | Advance on Nattokinase Microbial Production and Physiological Function |
| title_sort | advance on nattokinase microbial production and physiological function |
| topic | nattokinase bacillus subtilis (natto) production by microbial fermentation physiological function |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021070016 |
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