Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trial
Background and objectives: This clinical trial aimed to evaluate the effects of two different inhalation anesthetic agents on postoperative olfactory memory and olfactory function in patients who underwent micro laryngeal surgery. Methods: This randomized prospective controlled study consisted of 10...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Brazilian Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001420300099 |
| _version_ | 1811253650911133696 |
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| author | Huseyin Sari Yavuz Atar Tarkan Mingir Tolgar Lutfi Kumral Muhammed Fatih Akgun Esmail Abdulahi Ahmed Imran Aydogdu Ziya Salturk Guler Berkiten Yavuz Uyar |
| author_facet | Huseyin Sari Yavuz Atar Tarkan Mingir Tolgar Lutfi Kumral Muhammed Fatih Akgun Esmail Abdulahi Ahmed Imran Aydogdu Ziya Salturk Guler Berkiten Yavuz Uyar |
| author_sort | Huseyin Sari |
| collection | DOAJ |
| description | Background and objectives: This clinical trial aimed to evaluate the effects of two different inhalation anesthetic agents on postoperative olfactory memory and olfactory function in patients who underwent micro laryngeal surgery. Methods: This randomized prospective controlled study consisted of 102 consecutive patients with a voice disorder. The patients underwent micro laryngeal surgery for voice disorders under general anesthesia. Patients who did not meet inclusion criteria and/or declined to participate (n = 34) were excluded from the study. Patients were divided into two groups. Four patients from Group 1 and four patients from Group 2 were lost to follow-up. Group 1 (n = 30) received sevoflurane, and Group 2 (n = 30) received desflurane during anesthesia. We compared the results by performing the pre-op and post-op Connecticut Chemosensory Clinical Research Center Olfactory test. Results: Thirty-three patients (55%) were male and 27 (45%) were female. The mean age was 48.18 ± 13.88 years (range: 19‒70 years). Preoperative and postoperative olfactory functions did not show a significant difference within the groups postoperatively (p > 0.05). Preoperative and postoperative olfactory memory showed a significant decrease 3 hours after the surgery (p < 0.05). Conclusions: Olfactory functions and memory were not affected by desflurane in the early postoperative period. Although sevoflurane did not affect olfactory functions, it had a temporary negative effect on olfactory memory in the early postoperative period. Resumo: Introdução e objetivos: O estudo avaliou o efeito pós-operatório de dois agentes anestésicos inalatórios distinto na memória olfativa de curta duração e na função olfativa em pacientes submetidos à microcirurgia de laringe. Método: O estudo prospectivo controlado randomizado avaliou, consecutivamente, 102 pacientes com alteração vocal submetidos à microcirurgia de laringe sob anestesia geral. Trinta e quatro pacientes não obedeceram aos critérios de inclusão e/ou não aceitaram participar do estudo e foram excluídos. Os pacientes foram divididos em dois grupos. Quatro pacientes do Grupo 1 e quatro do Grupo 2 foram perdidos durante o seguimento. O Grupo 1 (n = 30) recebeu sevoflurano e o Grupo 2 (n = 30) desflurano durante a anestesia. Comparamos resultados pré e pós-operatórios de memória olfativa e funções olfativas, realizando o Connecticut Chemosensory Clinical Research Center Olfactory test. Resultados: Foram incluídos um total de 33 (55%) homens e 27 (45% mulheres. A idade média foi 48,18 ± 13,88 anos variação: 19‒70 anos). As funções olfativas pré e pós-operatórias não apresentaram diferença estatisticamente significante dentro dos grupos no pós-operatório (p > 0,05). A memória olfativa pré e pós-operatória não mostrou diminuição estatisticamente significante quando avaliada três horas após a cirurgia (p < 0,05). Conclusões: Memória e funções olfativas não foram alteradas pelo desflurano no pós-operatório imediato. Embora o sevoflurano não tenha alterado as funções olfativas, causou efeito temporário negativo na memória olfativa no pós-operatório imediato. |
| first_indexed | 2024-04-12T16:55:10Z |
| format | Article |
| id | doaj.art-eaa7dda4bca9491aa7aca46463fa8486 |
| institution | Directory Open Access Journal |
| issn | 0104-0014 |
| language | English |
| last_indexed | 2024-04-12T16:55:10Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj.art-eaa7dda4bca9491aa7aca46463fa84862022-12-22T03:24:17ZengElsevierBrazilian Journal of Anesthesiology0104-00142020-01-017013641Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trialHuseyin Sari0Yavuz Atar1Tarkan Mingir2Tolgar Lutfi Kumral3Muhammed Fatih Akgun4Esmail Abdulahi Ahmed5Imran Aydogdu6Ziya Salturk7Guler Berkiten8Yavuz Uyar9Okmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey; Corresponding author.Okmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, TurkeyOkmeydanı Training and Research Hospital, Department of Anesthesiology, Istanbul, TurkeyOkmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, TurkeyOkmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, TurkeyOkmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, TurkeyOkmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, TurkeyOkmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, TurkeyOkmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, TurkeyOkmeydanı Training and Research Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, TurkeyBackground and objectives: This clinical trial aimed to evaluate the effects of two different inhalation anesthetic agents on postoperative olfactory memory and olfactory function in patients who underwent micro laryngeal surgery. Methods: This randomized prospective controlled study consisted of 102 consecutive patients with a voice disorder. The patients underwent micro laryngeal surgery for voice disorders under general anesthesia. Patients who did not meet inclusion criteria and/or declined to participate (n = 34) were excluded from the study. Patients were divided into two groups. Four patients from Group 1 and four patients from Group 2 were lost to follow-up. Group 1 (n = 30) received sevoflurane, and Group 2 (n = 30) received desflurane during anesthesia. We compared the results by performing the pre-op and post-op Connecticut Chemosensory Clinical Research Center Olfactory test. Results: Thirty-three patients (55%) were male and 27 (45%) were female. The mean age was 48.18 ± 13.88 years (range: 19‒70 years). Preoperative and postoperative olfactory functions did not show a significant difference within the groups postoperatively (p > 0.05). Preoperative and postoperative olfactory memory showed a significant decrease 3 hours after the surgery (p < 0.05). Conclusions: Olfactory functions and memory were not affected by desflurane in the early postoperative period. Although sevoflurane did not affect olfactory functions, it had a temporary negative effect on olfactory memory in the early postoperative period. Resumo: Introdução e objetivos: O estudo avaliou o efeito pós-operatório de dois agentes anestésicos inalatórios distinto na memória olfativa de curta duração e na função olfativa em pacientes submetidos à microcirurgia de laringe. Método: O estudo prospectivo controlado randomizado avaliou, consecutivamente, 102 pacientes com alteração vocal submetidos à microcirurgia de laringe sob anestesia geral. Trinta e quatro pacientes não obedeceram aos critérios de inclusão e/ou não aceitaram participar do estudo e foram excluídos. Os pacientes foram divididos em dois grupos. Quatro pacientes do Grupo 1 e quatro do Grupo 2 foram perdidos durante o seguimento. O Grupo 1 (n = 30) recebeu sevoflurano e o Grupo 2 (n = 30) desflurano durante a anestesia. Comparamos resultados pré e pós-operatórios de memória olfativa e funções olfativas, realizando o Connecticut Chemosensory Clinical Research Center Olfactory test. Resultados: Foram incluídos um total de 33 (55%) homens e 27 (45% mulheres. A idade média foi 48,18 ± 13,88 anos variação: 19‒70 anos). As funções olfativas pré e pós-operatórias não apresentaram diferença estatisticamente significante dentro dos grupos no pós-operatório (p > 0,05). A memória olfativa pré e pós-operatória não mostrou diminuição estatisticamente significante quando avaliada três horas após a cirurgia (p < 0,05). Conclusões: Memória e funções olfativas não foram alteradas pelo desflurano no pós-operatório imediato. Embora o sevoflurano não tenha alterado as funções olfativas, causou efeito temporário negativo na memória olfativa no pós-operatório imediato.http://www.sciencedirect.com/science/article/pii/S0104001420300099Memória olfativaAnestesia inalatóriaDesfluranoSevoflurano |
| spellingShingle | Huseyin Sari Yavuz Atar Tarkan Mingir Tolgar Lutfi Kumral Muhammed Fatih Akgun Esmail Abdulahi Ahmed Imran Aydogdu Ziya Salturk Guler Berkiten Yavuz Uyar Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trial Brazilian Journal of Anesthesiology Memória olfativa Anestesia inalatória Desflurano Sevoflurano |
| title | Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trial |
| title_full | Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trial |
| title_fullStr | Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trial |
| title_full_unstemmed | Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trial |
| title_short | Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trial |
| title_sort | short term olfactory memory and olfactory function after inhalation anesthetic agents a randomized clinical trial |
| topic | Memória olfativa Anestesia inalatória Desflurano Sevoflurano |
| url | http://www.sciencedirect.com/science/article/pii/S0104001420300099 |
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