Structural insights into the C-terminus of the histone-lysine N-methyltransferase NSD3 by small-angle X-ray scattering

Structural insights into the C-terminus of the histone-lysine N-methyltransferase NSD3 by small-angle X-ray scattering

NSD3 is a member of six H3K36-specific histone lysine methyltransferases in metazoans. Its overexpression or mutation is implicated in developmental defects and oncogenesis. Aside from the well-characterized catalytic SET domain, NSD3 has multiple clinically relevant potential chromatin-binding moti...

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Bibliographic Details
Main Authors: Benny Danilo Belviso, Yunpeng Shen, Benedetta Carrozzini, Masayo Morishita, Eric di Luccio, Rocco Caliandro
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
nuclear receptor-binding SET domain protein 3
small-angle X-ray scattering
computational modeling
epigenetic cancer therapy
molecular dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1191246/full

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