Human Lung Cancer (A549) Cell Line Cytotoxicity and Anti-<i>Leishmania major</i> Activity of <i>Carissa macrocarpa</i> Leaves: A Study Supported by UPLC-ESI-MS/MS Metabolites Profiling and Molecular Docking

Human Lung Cancer (A549) Cell Line Cytotoxicity and Anti-<i>Leishmania major</i> Activity of <i>Carissa macrocarpa</i> Leaves: A Study Supported by UPLC-ESI-MS/MS Metabolites Profiling and Molecular Docking

Lung cancer and cutaneous leishmaniasis are critical diseases with a relatively higher incidence in developing countries. In this research, the activity of <i>Carissa macrocarpa</i> leaf hydromethanolic extract and its solvent-fractions (<i>n</i>-hexane, EtOAc, <i>n<...

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Bibliographic Details
Main Authors: Mohamed A. A. Orabi, Omaish Salman Alqahtani, Bandar A. Alyami, Ahmed Abdullah Al Awadh, El-Shaymaa Abdel-Sattar, Katsuyoshi Matsunami, Dalia I. Hamdan, Mohamed E. Abouelela
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceuticals
Subjects:
<i>Carissa macrocarpa</i>
cytotoxicity
A549
<i>Leishmania major</i>
UPLC-ESI-MS/MS
HDAC6
Online Access:https://www.mdpi.com/1424-8247/15/12/1561

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