Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: Correlation with myocardial remodeling
Background and aims: Cardiomyocyte hypertrophy and interstitial fibrosis are key components of myocardial remodeling in Heart Failure (HF) with preserved (HFpEF) or reduced ejection fraction (HFrEF). MicroRNAs (miRNAs) are non-coding, evolutionarily conserved RNA molecules that may offer novel insig...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024032377 |
| _version_ | 1827294085311889408 |
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| author | Layde Rosane Paim Luis Miguel da Silva Lígia M. Antunes-Correa Vinicius Citelli Ribeiro Roberto Schreiber Eduarda O.Z. Minin Larissa C.M. Bueno Elisangela C.P. Lopes Renan Yamaguti Andréa Coy-Canguçu Sergio San Juan Dertkigil Andrei Sposito Jose Roberto Matos-Souza Thiago Quinaglia Tomas G. Neilan Licio A. Velloso Wilson Nadruz Michael Jerosch-Herold Otavio R. Coelho-Filho |
| author_facet | Layde Rosane Paim Luis Miguel da Silva Lígia M. Antunes-Correa Vinicius Citelli Ribeiro Roberto Schreiber Eduarda O.Z. Minin Larissa C.M. Bueno Elisangela C.P. Lopes Renan Yamaguti Andréa Coy-Canguçu Sergio San Juan Dertkigil Andrei Sposito Jose Roberto Matos-Souza Thiago Quinaglia Tomas G. Neilan Licio A. Velloso Wilson Nadruz Michael Jerosch-Herold Otavio R. Coelho-Filho |
| author_sort | Layde Rosane Paim |
| collection | DOAJ |
| description | Background and aims: Cardiomyocyte hypertrophy and interstitial fibrosis are key components of myocardial remodeling in Heart Failure (HF) with preserved (HFpEF) or reduced ejection fraction (HFrEF). MicroRNAs (miRNAs) are non-coding, evolutionarily conserved RNA molecules that may offer novel insights into myocardial remodeling. This study aimed to characterize miRNA expression in HFpEF (LVEF ≥ 45%) and HFrEF (LVEF < 45%) and its association with myocardial remodeling. Methods: Prospectively enrolled symptomatic HF patients (HFpEF:n = 36; HFrEF:n = 31) and controls (n = 23) underwent cardiac magnetic resonance imaging with T1-mapping and circulating miRNA expression (OpenArray system). Results: 13 of 188 miRNAs were differentially expressed between HF groups (11 downregulated in HFpEF). Myocardial extracellular volume (ECV) was increased in both HF groups (HFpEF 30 ± 5%; HFrEF 30 ± 3%; controls 26 ± 2%, p < 0.001). miR-128a-3p, linked to cardiac hypertrophy, fibrosis, and dysfunction, correlated positively with ECV in HFpEF (r = 0.60, p = 0.01) and negatively in HFrEF (r = −0.51, p = 0.04). miR-423-5p overexpression, previously associated HF mortality, was inversely associated with LVEF (r = − 0.29, p = 0.04) and intracellular water lifetime (τic) (r = −0.45, p < 0.05) in both HF groups, and with NT-proBNP in HFpEF (r = −0.63, p < 0.01). Conclusions: miRNA expression profiles differed between HF phenotypes. The differential expression and association of miR-128a-3p with ECV may reflect the distinct vascular, interstitial, and cellular etiologies of HF phenotypes. |
| first_indexed | 2024-04-24T13:50:56Z |
| format | Article |
| id | doaj.art-eaa9d3f818ab46b9aaa81b7cf96f7904 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:50:56Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-eaa9d3f818ab46b9aaa81b7cf96f79042024-04-04T05:04:27ZengElsevierHeliyon2405-84402024-03-01106e27206Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: Correlation with myocardial remodelingLayde Rosane Paim0Luis Miguel da Silva1Lígia M. Antunes-Correa2Vinicius Citelli Ribeiro3Roberto Schreiber4Eduarda O.Z. Minin5Larissa C.M. Bueno6Elisangela C.P. Lopes7Renan Yamaguti8Andréa Coy-Canguçu9Sergio San Juan Dertkigil10Andrei Sposito11Jose Roberto Matos-Souza12Thiago Quinaglia13Tomas G. Neilan14Licio A. Velloso15Wilson Nadruz16Michael Jerosch-Herold17Otavio R. Coelho-Filho18Faculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Engenharia Elétrica e de Computação – Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Medicina – Pontifícia Universidade Católica de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, Brazil; Cardiovascular Imaging Research Center, Division of Cardiology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USACardiovascular Imaging Research Center, Division of Cardiology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, BrazilNon-Invasive Cardiovascular Imaging Program, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAFaculdade de Ciências Médicas - Universidade Estadual de Campinas, São Paulo, Brazil; Corresponding author. School of Medical Science, University of Campinas - UNICAMP, Rua Tessália Vieira de Camargo, 126 - Cidade Universitária ''Zeferino Vaz'', Campinas - SP CEP: 13083-887, Brazil.Background and aims: Cardiomyocyte hypertrophy and interstitial fibrosis are key components of myocardial remodeling in Heart Failure (HF) with preserved (HFpEF) or reduced ejection fraction (HFrEF). MicroRNAs (miRNAs) are non-coding, evolutionarily conserved RNA molecules that may offer novel insights into myocardial remodeling. This study aimed to characterize miRNA expression in HFpEF (LVEF ≥ 45%) and HFrEF (LVEF < 45%) and its association with myocardial remodeling. Methods: Prospectively enrolled symptomatic HF patients (HFpEF:n = 36; HFrEF:n = 31) and controls (n = 23) underwent cardiac magnetic resonance imaging with T1-mapping and circulating miRNA expression (OpenArray system). Results: 13 of 188 miRNAs were differentially expressed between HF groups (11 downregulated in HFpEF). Myocardial extracellular volume (ECV) was increased in both HF groups (HFpEF 30 ± 5%; HFrEF 30 ± 3%; controls 26 ± 2%, p < 0.001). miR-128a-3p, linked to cardiac hypertrophy, fibrosis, and dysfunction, correlated positively with ECV in HFpEF (r = 0.60, p = 0.01) and negatively in HFrEF (r = −0.51, p = 0.04). miR-423-5p overexpression, previously associated HF mortality, was inversely associated with LVEF (r = − 0.29, p = 0.04) and intracellular water lifetime (τic) (r = −0.45, p < 0.05) in both HF groups, and with NT-proBNP in HFpEF (r = −0.63, p < 0.01). Conclusions: miRNA expression profiles differed between HF phenotypes. The differential expression and association of miR-128a-3p with ECV may reflect the distinct vascular, interstitial, and cellular etiologies of HF phenotypes.http://www.sciencedirect.com/science/article/pii/S2405844024032377Heart failureBiomarkersMicroRNAInterstitial fibrosisMyocardial remodeling |
| spellingShingle | Layde Rosane Paim Luis Miguel da Silva Lígia M. Antunes-Correa Vinicius Citelli Ribeiro Roberto Schreiber Eduarda O.Z. Minin Larissa C.M. Bueno Elisangela C.P. Lopes Renan Yamaguti Andréa Coy-Canguçu Sergio San Juan Dertkigil Andrei Sposito Jose Roberto Matos-Souza Thiago Quinaglia Tomas G. Neilan Licio A. Velloso Wilson Nadruz Michael Jerosch-Herold Otavio R. Coelho-Filho Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: Correlation with myocardial remodeling Heliyon Heart failure Biomarkers MicroRNA Interstitial fibrosis Myocardial remodeling |
| title | Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: Correlation with myocardial remodeling |
| title_full | Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: Correlation with myocardial remodeling |
| title_fullStr | Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: Correlation with myocardial remodeling |
| title_full_unstemmed | Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: Correlation with myocardial remodeling |
| title_short | Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: Correlation with myocardial remodeling |
| title_sort | profile of serum micrornas in heart failure with reduced and preserved ejection fraction correlation with myocardial remodeling |
| topic | Heart failure Biomarkers MicroRNA Interstitial fibrosis Myocardial remodeling |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024032377 |
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