Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor
Abstract Biomaterials traditionally used for wound healing can act as a temporary barrier to halt bleeding, prevent infection, and enhance regeneration. Hydrogels are among the best candidates for wound healing owing to their moisture retention and drug-releasing properties. Photo-polymerization usi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-02589-1 |
| _version_ | 1818345023045894144 |
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| author | Toshihiro Kushibiki Yoshine Mayumi Eiko Nakayama Ryuichi Azuma Kenichiro Ojima Akio Horiguchi Miya Ishihara |
| author_facet | Toshihiro Kushibiki Yoshine Mayumi Eiko Nakayama Ryuichi Azuma Kenichiro Ojima Akio Horiguchi Miya Ishihara |
| author_sort | Toshihiro Kushibiki |
| collection | DOAJ |
| description | Abstract Biomaterials traditionally used for wound healing can act as a temporary barrier to halt bleeding, prevent infection, and enhance regeneration. Hydrogels are among the best candidates for wound healing owing to their moisture retention and drug-releasing properties. Photo-polymerization using visible light irradiation is a promising method for hydrogel preparation since it can easily control spatiotemporal reaction kinetics and rapidly induce a single-step reaction under mild conditions. In this study, photocrosslinked gelatin hydrogels were imparted with properties namely fast wound adherence, strong wet tissue surface adhesion, greater biocompatibility, long-term bFGF release, and importantly, ease of use through the modification and combination of natural bio-macromolecules. The production of a gelatin hydrogel made of natural gelatin (which is superior to chemically modified gelatin), crosslinked by visible light, which is more desirable than UV light irradiation, will enable its prolonged application to uneven wound surfaces. This is due to its flexible shape, along with the administration of cell growth factors, such as bFGF, for tissue regeneration. Further, the sustained release of bFGF enhances wound healing and skin flap survival. The photocrosslinking gelatin hydrogel designed in this study is a potential candidate to enhance wound healing and better skin flap survival. |
| first_indexed | 2024-12-13T16:55:46Z |
| format | Article |
| id | doaj.art-eaaadea52ac54d1592ce8946890df160 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T16:55:46Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-eaaadea52ac54d1592ce8946890df1602022-12-21T23:37:55ZengNature PortfolioScientific Reports2045-23222021-11-0111111210.1038/s41598-021-02589-1Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factorToshihiro Kushibiki0Yoshine Mayumi1Eiko Nakayama2Ryuichi Azuma3Kenichiro Ojima4Akio Horiguchi5Miya Ishihara6Department of Medical Engineering, National Defense Medical CollegeDepartment of Medical Engineering, National Defense Medical CollegeDepartment of Plastic Surgery, National Defense Medical CollegeDepartment of Plastic Surgery, National Defense Medical CollegeDepartment of Urology, National Defense Medical CollegeDepartment of Urology, National Defense Medical CollegeDepartment of Medical Engineering, National Defense Medical CollegeAbstract Biomaterials traditionally used for wound healing can act as a temporary barrier to halt bleeding, prevent infection, and enhance regeneration. Hydrogels are among the best candidates for wound healing owing to their moisture retention and drug-releasing properties. Photo-polymerization using visible light irradiation is a promising method for hydrogel preparation since it can easily control spatiotemporal reaction kinetics and rapidly induce a single-step reaction under mild conditions. In this study, photocrosslinked gelatin hydrogels were imparted with properties namely fast wound adherence, strong wet tissue surface adhesion, greater biocompatibility, long-term bFGF release, and importantly, ease of use through the modification and combination of natural bio-macromolecules. The production of a gelatin hydrogel made of natural gelatin (which is superior to chemically modified gelatin), crosslinked by visible light, which is more desirable than UV light irradiation, will enable its prolonged application to uneven wound surfaces. This is due to its flexible shape, along with the administration of cell growth factors, such as bFGF, for tissue regeneration. Further, the sustained release of bFGF enhances wound healing and skin flap survival. The photocrosslinking gelatin hydrogel designed in this study is a potential candidate to enhance wound healing and better skin flap survival.https://doi.org/10.1038/s41598-021-02589-1 |
| spellingShingle | Toshihiro Kushibiki Yoshine Mayumi Eiko Nakayama Ryuichi Azuma Kenichiro Ojima Akio Horiguchi Miya Ishihara Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor Scientific Reports |
| title | Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor |
| title_full | Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor |
| title_fullStr | Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor |
| title_full_unstemmed | Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor |
| title_short | Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor |
| title_sort | photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor |
| url | https://doi.org/10.1038/s41598-021-02589-1 |
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