The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes
In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discusse...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/10/2956 |
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| author | Marta S. Krawczyk Adam Sroka Irena Majerz |
| author_facet | Marta S. Krawczyk Adam Sroka Irena Majerz |
| author_sort | Marta S. Krawczyk |
| collection | DOAJ |
| description | In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discussed. Formation of the crystals is determined by the presence of the intermolecular O–H<sup>…</sup>N hydrogen bond that occur between fenamic acids and acridine. Intermolecular interactions stabilizing the crystals such as π<sup>…</sup>π stacking, C–H<sup>…</sup>X (X = O, Cl) intermolecular hydrogen bonds as well as C–H<sup>…</sup>π and other dispersive interactions were analyzed by theoretical methods: the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction (NCI) approaches. |
| first_indexed | 2024-03-10T11:22:28Z |
| format | Article |
| id | doaj.art-eaaae85f4446424ebd074cfbf1345e04 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:22:28Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-eaaae85f4446424ebd074cfbf1345e042023-11-21T19:57:34ZengMDPI AGMolecules1420-30492021-05-012610295610.3390/molecules26102956The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine ComplexesMarta S. Krawczyk0Adam Sroka1Irena Majerz2Faculty of Pharmacy, Wrocław Medical University, Borowska 211a, 50-556 Wrocław, PolandFaculty of Pharmacy, Wrocław Medical University, Borowska 211a, 50-556 Wrocław, PolandFaculty of Pharmacy, Wrocław Medical University, Borowska 211a, 50-556 Wrocław, PolandIn order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discussed. Formation of the crystals is determined by the presence of the intermolecular O–H<sup>…</sup>N hydrogen bond that occur between fenamic acids and acridine. Intermolecular interactions stabilizing the crystals such as π<sup>…</sup>π stacking, C–H<sup>…</sup>X (X = O, Cl) intermolecular hydrogen bonds as well as C–H<sup>…</sup>π and other dispersive interactions were analyzed by theoretical methods: the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction (NCI) approaches.https://www.mdpi.com/1420-3049/26/10/2956fenamic acidsacridinecomplexQTAIMNCI approach |
| spellingShingle | Marta S. Krawczyk Adam Sroka Irena Majerz The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes Molecules fenamic acids acridine complex QTAIM NCI approach |
| title | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
| title_full | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
| title_fullStr | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
| title_full_unstemmed | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
| title_short | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
| title_sort | crystal structure and intermolecular interactions in fenamic acids acridine complexes |
| topic | fenamic acids acridine complex QTAIM NCI approach |
| url | https://www.mdpi.com/1420-3049/26/10/2956 |
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