T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants.

T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants.

The fine-tuning of neuronal excitability relies on a tight control of Ca2+ homeostasis. The low voltage-activated T-type calcium channels (Cav3.1, Cav3.2 and Cav3.3 isoforms) play a critical role in regulating these processes. Despite their wide expression throughout the central nervous system, the...

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Bibliographic Details
Main Authors: Giuseppe eGangarossa, Sophie eLaffray, Emmanuel eBourinet, Emmanuel eValjent
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Anxiety
drugs of abuse
Psychostimulants
memory and learning
spontaneous behavior
T-type Ca2+ channels
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00092/full

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