Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis
BackgroundStudies evaluating the relationship between intrauterine hematoma in the first trimester and prenatal complications are conflicting.ObjectivesTo evaluate whether intrauterine hematoma identified in the first trimester in women with singleton pregnancies is associated with adverse perinatal...
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.892146/full |
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| author | Zhao-juan Qin Zhao-juan Qin Yu Xu Yu Xu Yi Du Yi Du Ya-li Chen Ya-li Chen Liang Sun Liang Sun Ai Zheng Ai Zheng |
| author_facet | Zhao-juan Qin Zhao-juan Qin Yu Xu Yu Xu Yi Du Yi Du Ya-li Chen Ya-li Chen Liang Sun Liang Sun Ai Zheng Ai Zheng |
| author_sort | Zhao-juan Qin |
| collection | DOAJ |
| description | BackgroundStudies evaluating the relationship between intrauterine hematoma in the first trimester and prenatal complications are conflicting.ObjectivesTo evaluate whether intrauterine hematoma identified in the first trimester in women with singleton pregnancies is associated with adverse perinatal outcomes.Search StrategyA comprehensive literature search of three databases (Embase, PubMed, and Web of Science) was performed up to September 2021.Selection CriteriaCohort and case-control studies that have evaluated the relationship between intrauterine hematoma identified before 14 gestational weeks and the risk of prenatal complications, in women with a singleton pregnancy.Data Collection and AnalysisTwo members of our team independently assessed the studies for inclusion, collected the data of interest, and assessed the risk of bias, and calculated pooled odds ratios (ORs) using random-effects models.Main ResultsNine studies, including 1,132 women with intrauterine hematoma and 11,179 controls met the inclusion criteria. Intrauterine hematoma increased the risk of spontaneous abortion [OR 2.15, 95% confidence interval (CI) 1.23–3.75], preterm birth (OR 1.83, 95% CI 1.37–2.43), fetal growth restriction (OR 2.33, 95% CI 1.13–4.83) and placental abruption (OR 3.16, 95% CI 1.23–8.13). No statistically significant association was found between intrauterine hematoma and preeclampsia (OR 1.30, 95% CI 0.87–1.94).ConclusionIntrauterine hematoma in the first trimester of pregnancy increases the risk of spontaneous abortion, preterm birth, placental abruption, and fetal growth restriction.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/. |
| first_indexed | 2024-12-12T12:34:53Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T12:34:53Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-eaacfdd982ed43c78e1e708578c8586d2022-12-22T00:24:22ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.892146892146Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-AnalysisZhao-juan Qin0Zhao-juan Qin1Yu Xu2Yu Xu3Yi Du4Yi Du5Ya-li Chen6Ya-li Chen7Liang Sun8Liang Sun9Ai Zheng10Ai Zheng11Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaLaboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaLaboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaLaboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaLaboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaLaboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaLaboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Sichuan University, Chengdu, ChinaBackgroundStudies evaluating the relationship between intrauterine hematoma in the first trimester and prenatal complications are conflicting.ObjectivesTo evaluate whether intrauterine hematoma identified in the first trimester in women with singleton pregnancies is associated with adverse perinatal outcomes.Search StrategyA comprehensive literature search of three databases (Embase, PubMed, and Web of Science) was performed up to September 2021.Selection CriteriaCohort and case-control studies that have evaluated the relationship between intrauterine hematoma identified before 14 gestational weeks and the risk of prenatal complications, in women with a singleton pregnancy.Data Collection and AnalysisTwo members of our team independently assessed the studies for inclusion, collected the data of interest, and assessed the risk of bias, and calculated pooled odds ratios (ORs) using random-effects models.Main ResultsNine studies, including 1,132 women with intrauterine hematoma and 11,179 controls met the inclusion criteria. Intrauterine hematoma increased the risk of spontaneous abortion [OR 2.15, 95% confidence interval (CI) 1.23–3.75], preterm birth (OR 1.83, 95% CI 1.37–2.43), fetal growth restriction (OR 2.33, 95% CI 1.13–4.83) and placental abruption (OR 3.16, 95% CI 1.23–8.13). No statistically significant association was found between intrauterine hematoma and preeclampsia (OR 1.30, 95% CI 0.87–1.94).ConclusionIntrauterine hematoma in the first trimester of pregnancy increases the risk of spontaneous abortion, preterm birth, placental abruption, and fetal growth restriction.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/.https://www.frontiersin.org/articles/10.3389/fmed.2022.892146/fullintrauterine hematomasingleton pregnancyfirst trimesterprenatal complicationsspontaneous abortion |
| spellingShingle | Zhao-juan Qin Zhao-juan Qin Yu Xu Yu Xu Yi Du Yi Du Ya-li Chen Ya-li Chen Liang Sun Liang Sun Ai Zheng Ai Zheng Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis Frontiers in Medicine intrauterine hematoma singleton pregnancy first trimester prenatal complications spontaneous abortion |
| title | Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis |
| title_full | Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis |
| title_fullStr | Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis |
| title_short | Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis |
| title_sort | intrauterine hematoma in the first trimester and pregnancy complications a systematic review and meta analysis |
| topic | intrauterine hematoma singleton pregnancy first trimester prenatal complications spontaneous abortion |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.892146/full |
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