The role of the P2X₇ receptor in infectious diseases.
ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X₇ receptor opens a cation-specific channel that alters the ionic environme...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-11-01
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| Series: | PLoS Pathogens |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22102807/?tool=EBI |
| _version_ | 1818993166587527168 |
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| author | Catherine M Miller Nicola R Boulter Stephen J Fuller Alana M Zakrzewski Michael P Lees Bernadette M Saunders James S Wiley Nicholas C Smith |
| author_facet | Catherine M Miller Nicola R Boulter Stephen J Fuller Alana M Zakrzewski Michael P Lees Bernadette M Saunders James S Wiley Nicholas C Smith |
| author_sort | Catherine M Miller |
| collection | DOAJ |
| description | ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X₇ receptor opens a cation-specific channel that alters the ionic environment of the cell, activating several pathways, including (i) the inflammasome, leading to production of IL-1β and IL-18; (ii) the stress-activated protein kinase pathway, resulting in apoptosis; (iii) the mitogen-activated protein kinase pathway, leading to generation of reactive oxygen and nitrogen intermediates; and (iv) phospholipase D, stimulating phagosome-lysosome fusion. The P2X₇ receptor can initiate host mechanisms to remove pathogens, most particularly those that parasitise macrophages. At the same time, the P2X₇ receptor may be subverted by pathogens to modulate host responses. Moreover, recent genetic studies have demonstrated significant associations between susceptibility or resistance to parasites and bacteria, and loss-of-function or gain-of-function polymorphisms in the P2X₇ receptor, underscoring its importance in infectious disease. |
| first_indexed | 2024-12-20T20:37:44Z |
| format | Article |
| id | doaj.art-eaae2f5f8dfd4171bed244a273cb96bf |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-20T20:37:44Z |
| publishDate | 2011-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-eaae2f5f8dfd4171bed244a273cb96bf2022-12-21T19:27:12ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742011-11-01711e100221210.1371/journal.ppat.1002212The role of the P2X₇ receptor in infectious diseases.Catherine M MillerNicola R BoulterStephen J FullerAlana M ZakrzewskiMichael P LeesBernadette M SaundersJames S WileyNicholas C SmithATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X₇ receptor opens a cation-specific channel that alters the ionic environment of the cell, activating several pathways, including (i) the inflammasome, leading to production of IL-1β and IL-18; (ii) the stress-activated protein kinase pathway, resulting in apoptosis; (iii) the mitogen-activated protein kinase pathway, leading to generation of reactive oxygen and nitrogen intermediates; and (iv) phospholipase D, stimulating phagosome-lysosome fusion. The P2X₇ receptor can initiate host mechanisms to remove pathogens, most particularly those that parasitise macrophages. At the same time, the P2X₇ receptor may be subverted by pathogens to modulate host responses. Moreover, recent genetic studies have demonstrated significant associations between susceptibility or resistance to parasites and bacteria, and loss-of-function or gain-of-function polymorphisms in the P2X₇ receptor, underscoring its importance in infectious disease.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22102807/?tool=EBI |
| spellingShingle | Catherine M Miller Nicola R Boulter Stephen J Fuller Alana M Zakrzewski Michael P Lees Bernadette M Saunders James S Wiley Nicholas C Smith The role of the P2X₇ receptor in infectious diseases. PLoS Pathogens |
| title | The role of the P2X₇ receptor in infectious diseases. |
| title_full | The role of the P2X₇ receptor in infectious diseases. |
| title_fullStr | The role of the P2X₇ receptor in infectious diseases. |
| title_full_unstemmed | The role of the P2X₇ receptor in infectious diseases. |
| title_short | The role of the P2X₇ receptor in infectious diseases. |
| title_sort | role of the p2x₇ receptor in infectious diseases |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22102807/?tool=EBI |
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