Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study
Vitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. We assessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine vari...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2013-01-01
|
| Series: | Journal of Nutritional Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679012000286/type/journal_article |
| _version_ | 1811156023735484416 |
|---|---|
| author | Cornelia M. Ulrich Adetunji T. Toriola Erin M. Siegel Hermann Brenner Jenny Chang-Claude Clare Abbenhardt Jana Kotzmann Xiaoling Song Robert W. Owen Michael Hoffmeister Heiko Becher David Shibata Kathy Vickers Shannon K. Rush Karen Makar Gerd Würtele Roswitha Haubner Thomas A. Sellers William Grady |
| author_facet | Cornelia M. Ulrich Adetunji T. Toriola Erin M. Siegel Hermann Brenner Jenny Chang-Claude Clare Abbenhardt Jana Kotzmann Xiaoling Song Robert W. Owen Michael Hoffmeister Heiko Becher David Shibata Kathy Vickers Shannon K. Rush Karen Makar Gerd Würtele Roswitha Haubner Thomas A. Sellers William Grady |
| author_sort | Cornelia M. Ulrich |
| collection | DOAJ |
| description | Vitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. We assessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine variability of these biomarkers based on geographical location. Plasma 25(OH)D3, folate and vitamin B12 concentrations were measured in 149 invasive, newly diagnosed colorectal cancer cases from Heidelberg (Germany), Seattle (WA, USA), and Tampa (FL, USA) and in ninety-one age- and sex-matched controls. Their associations with potential predictors were assessed using multivariate linear regression analyses. Plasma 25(OH)D3, folate and vitamin B12 concentrations differed by location. Other predictors were season for 25(OH)D3 and tumour stage (vitamin B12). Season-corrected average 25(OH)D3 concentrations were higher in Heidelberg (31·7 ng/ml; range 11·0–83·0 ng/ml) than in Seattle (23·3 ng/ml; range 4·0–80·0 ng/ml) and Tampa (21·1 ng/ml; range 4·6–51·6 ng/ml). In Heidelberg, a strong seasonal variation was observed. Folate (11·1 ng/ml) and vitamin B12 (395 pg/ml) concentrations in Heidelberg were lower than those in Seattle (25·3 ng/ml and 740 pg/ml, respectively) and Tampa (23·8 ng/ml and 522 pg/ml, respectively). Differences in plasma 25(OH)D3 and folate concentrations between Heidelberg and the US sites were observed, probably reflecting variation in outdoor activities and sun-avoidance behaviour during summer as well as in folic acid fortification and supplement use. Intra-site differences at each study location were greater than between-location variability, suggesting that individual health behaviours play a significant role. Nevertheless, the intra-site differences we observed may be due to chance because of the limited sample size. Our pilot study illustrates the value of an international cohort in studying colorectal cancer prognosis to discern geographical differences in a broad range of exposures. |
| first_indexed | 2024-04-10T04:44:32Z |
| format | Article |
| id | doaj.art-eaaeb8e9cd194b2497b550b77382d7c5 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:44:32Z |
| publishDate | 2013-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-eaaeb8e9cd194b2497b550b77382d7c52023-03-09T12:38:38ZengCambridge University PressJournal of Nutritional Science2048-67902013-01-01210.1017/jns.2012.28Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot studyCornelia M. Ulrich0Adetunji T. Toriola1Erin M. Siegel2Hermann Brenner3Jenny Chang-Claude4Clare Abbenhardt5Jana Kotzmann6Xiaoling Song7Robert W. Owen8Michael Hoffmeister9Heiko Becher10David Shibata11Kathy Vickers12Shannon K. Rush13Karen Makar14Gerd Würtele15Roswitha Haubner16Thomas A. Sellers17William Grady18Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany Fred Hutchinson Cancer Research Center, Seattle, WA, USADivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USAH. LeeMoffitt Cancer Center, Tampa, FL, USADivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, GermanyDivision of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, GermanyDivision of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, GermanyFred Hutchinson Cancer Research Center, Seattle, WA, USADivision of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, GermanyDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, GermanyUniversity of Heidelberg, Heidelberg, GermanyH. LeeMoffitt Cancer Center, Tampa, FL, USAFred Hutchinson Cancer Research Center, Seattle, WA, USAFred Hutchinson Cancer Research Center, Seattle, WA, USAFred Hutchinson Cancer Research Center, Seattle, WA, USADivision of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, GermanyDivision of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, GermanyH. LeeMoffitt Cancer Center, Tampa, FL, USAFred Hutchinson Cancer Research Center, Seattle, WA, USAVitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. We assessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine variability of these biomarkers based on geographical location. Plasma 25(OH)D3, folate and vitamin B12 concentrations were measured in 149 invasive, newly diagnosed colorectal cancer cases from Heidelberg (Germany), Seattle (WA, USA), and Tampa (FL, USA) and in ninety-one age- and sex-matched controls. Their associations with potential predictors were assessed using multivariate linear regression analyses. Plasma 25(OH)D3, folate and vitamin B12 concentrations differed by location. Other predictors were season for 25(OH)D3 and tumour stage (vitamin B12). Season-corrected average 25(OH)D3 concentrations were higher in Heidelberg (31·7 ng/ml; range 11·0–83·0 ng/ml) than in Seattle (23·3 ng/ml; range 4·0–80·0 ng/ml) and Tampa (21·1 ng/ml; range 4·6–51·6 ng/ml). In Heidelberg, a strong seasonal variation was observed. Folate (11·1 ng/ml) and vitamin B12 (395 pg/ml) concentrations in Heidelberg were lower than those in Seattle (25·3 ng/ml and 740 pg/ml, respectively) and Tampa (23·8 ng/ml and 522 pg/ml, respectively). Differences in plasma 25(OH)D3 and folate concentrations between Heidelberg and the US sites were observed, probably reflecting variation in outdoor activities and sun-avoidance behaviour during summer as well as in folic acid fortification and supplement use. Intra-site differences at each study location were greater than between-location variability, suggesting that individual health behaviours play a significant role. Nevertheless, the intra-site differences we observed may be due to chance because of the limited sample size. Our pilot study illustrates the value of an international cohort in studying colorectal cancer prognosis to discern geographical differences in a broad range of exposures.https://www.cambridge.org/core/product/identifier/S2048679012000286/type/journal_articleColorectal cancerSurvivalVitamin DVitamin B12 Folate |
| spellingShingle | Cornelia M. Ulrich Adetunji T. Toriola Erin M. Siegel Hermann Brenner Jenny Chang-Claude Clare Abbenhardt Jana Kotzmann Xiaoling Song Robert W. Owen Michael Hoffmeister Heiko Becher David Shibata Kathy Vickers Shannon K. Rush Karen Makar Gerd Würtele Roswitha Haubner Thomas A. Sellers William Grady Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study Journal of Nutritional Science Colorectal cancer Survival Vitamin D Vitamin B12 Folate |
| title | Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study |
| title_full | Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study |
| title_fullStr | Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study |
| title_full_unstemmed | Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study |
| title_short | Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study |
| title_sort | plasma 25 hydroxyvitamin d3 folate and vitamin b12 biomarkers among international colorectal cancer patients a pilot study |
| topic | Colorectal cancer Survival Vitamin D Vitamin B12 Folate |
| url | https://www.cambridge.org/core/product/identifier/S2048679012000286/type/journal_article |
| work_keys_str_mv | AT corneliamulrich plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT adetunjittoriola plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT erinmsiegel plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT hermannbrenner plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT jennychangclaude plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT clareabbenhardt plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT janakotzmann plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT xiaolingsong plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT robertwowen plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT michaelhoffmeister plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT heikobecher plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT davidshibata plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT kathyvickers plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT shannonkrush plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT karenmakar plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT gerdwurtele plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT roswithahaubner plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT thomasasellers plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy AT williamgrady plasma25hydroxyvitamind3folateandvitaminb12biomarkersamonginternationalcolorectalcancerpatientsapilotstudy |