IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions
Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in a...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/10/2184 |
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| author | Doreen M. Floss Jens M. Moll Jürgen Scheller |
| author_facet | Doreen M. Floss Jens M. Moll Jürgen Scheller |
| author_sort | Doreen M. Floss |
| collection | DOAJ |
| description | Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in autoimmune diseases, cancer and infections. Accordingly, structural knowledge about receptor complex formation is essential for the development of new therapeutic strategies preventing and/or inhibiting cytokine:receptor interaction. In addition, intracellular signaling cascades can be targeted to inhibit cytokine-mediated effects. Single nucleotide polymorphisms can lead to alteration in the amino acid sequence and thereby influencing protein functions or protein–protein interactions. To understand the biology of IL-12 and IL-23 and to establish efficient targeting strategies structural knowledge about cytokines and respective receptors is crucial. A highly efficient therapy might be a combination of different drugs targeting extracellular cytokine:receptor assembly and intracellular signaling pathways. |
| first_indexed | 2024-03-10T15:59:17Z |
| format | Article |
| id | doaj.art-eaaf16bbf8c04eec906976fa69521f60 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:59:17Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-eaaf16bbf8c04eec906976fa69521f602023-11-20T15:25:03ZengMDPI AGCells2073-44092020-09-01910218410.3390/cells9102184IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological FunctionsDoreen M. Floss0Jens M. Moll1Jürgen Scheller2Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, D-40225 Düsseldorf, GermanyInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, D-40225 Düsseldorf, GermanyInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, D-40225 Düsseldorf, GermanyCytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in autoimmune diseases, cancer and infections. Accordingly, structural knowledge about receptor complex formation is essential for the development of new therapeutic strategies preventing and/or inhibiting cytokine:receptor interaction. In addition, intracellular signaling cascades can be targeted to inhibit cytokine-mediated effects. Single nucleotide polymorphisms can lead to alteration in the amino acid sequence and thereby influencing protein functions or protein–protein interactions. To understand the biology of IL-12 and IL-23 and to establish efficient targeting strategies structural knowledge about cytokines and respective receptors is crucial. A highly efficient therapy might be a combination of different drugs targeting extracellular cytokine:receptor assembly and intracellular signaling pathways.https://www.mdpi.com/2073-4409/9/10/2184IL-12 family cytokinesIL-12IL-23signalingautoimmune diseases |
| spellingShingle | Doreen M. Floss Jens M. Moll Jürgen Scheller IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions Cells IL-12 family cytokines IL-12 IL-23 signaling autoimmune diseases |
| title | IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions |
| title_full | IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions |
| title_fullStr | IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions |
| title_full_unstemmed | IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions |
| title_short | IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions |
| title_sort | il 12 and il 23 close relatives with structural homologies but distinct immunological functions |
| topic | IL-12 family cytokines IL-12 IL-23 signaling autoimmune diseases |
| url | https://www.mdpi.com/2073-4409/9/10/2184 |
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