Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia
Persistent immune activation in virologically suppressed HIV-1 patients, which may be the consequence of various factors including microbial translocation, is a major cause of comorbidities. We have previously shown that different profiles of immune activation may be distinguished in virological res...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02185/full |
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| author | Mehwish Younas Christina Psomas Christina Psomas Christelle Reynes Renaud Cezar Lucy Kundura Pierre Portales Corinne Merle Nadine Atoui Céline Fernandez Vincent Le Moing Vincent Le Moing Vincent Le Moing Claudine Barbuat Olivier Moranne Albert Sotto Albert Sotto Robert Sabatier Pascale Fabbro Thierry Vincent Thierry Vincent Catherine Dunyach-Remy Audrey Winter Jacques Reynes Jacques Reynes Jacques Reynes Jean-Philippe Lavigne Pierre Corbeau Pierre Corbeau Pierre Corbeau |
| author_facet | Mehwish Younas Christina Psomas Christina Psomas Christelle Reynes Renaud Cezar Lucy Kundura Pierre Portales Corinne Merle Nadine Atoui Céline Fernandez Vincent Le Moing Vincent Le Moing Vincent Le Moing Claudine Barbuat Olivier Moranne Albert Sotto Albert Sotto Robert Sabatier Pascale Fabbro Thierry Vincent Thierry Vincent Catherine Dunyach-Remy Audrey Winter Jacques Reynes Jacques Reynes Jacques Reynes Jean-Philippe Lavigne Pierre Corbeau Pierre Corbeau Pierre Corbeau |
| author_sort | Mehwish Younas |
| collection | DOAJ |
| description | Persistent immune activation in virologically suppressed HIV-1 patients, which may be the consequence of various factors including microbial translocation, is a major cause of comorbidities. We have previously shown that different profiles of immune activation may be distinguished in virological responders. Here, we tested the hypothesis that a particular profile might be the consequence of microbial translocation. To this aim, we measured 64 soluble and cell surface markers of inflammation and CD4+ and CD8+ T-cell, B cell, monocyte, NK cell, and endothelial activation in 140 adults under efficient antiretroviral therapy, and classified patients and markers using a double hierarchical clustering analysis. We also measured the plasma levels of the microbial translocation markers bacterial DNA, lipopolysaccharide binding protein (LBP), intestinal-fatty acid binding protein, and soluble CD14. We identified five different immune activation profiles. Patients with an immune activation profile characterized by a high percentage of CD38+CD8+ T-cells and a high level of the endothelial activation marker soluble Thrombomodulin, presented with higher LBP mean (± SEM) concentrations (33.3 ± 1.7 vs. 28.7 ± 0.9 μg/mL, p = 0.025) than patients with other profiles. Our data are consistent with the hypothesis that the immune activation profiles we described are the result of different etiological factors. We propose a model, where particular causes of immune activation, as microbial translocation, drive particular immune activation profiles responsible for particular comorbidities. |
| first_indexed | 2024-12-12T15:33:49Z |
| format | Article |
| id | doaj.art-eaafa4540c4a4601bca6dc8a6da27e79 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T15:33:49Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-eaafa4540c4a4601bca6dc8a6da27e792022-12-22T00:20:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-09-011010.3389/fimmu.2019.02185474115Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed ViremiaMehwish Younas0Christina Psomas1Christina Psomas2Christelle Reynes3Renaud Cezar4Lucy Kundura5Pierre Portales6Corinne Merle7Nadine Atoui8Céline Fernandez9Vincent Le Moing10Vincent Le Moing11Vincent Le Moing12Claudine Barbuat13Olivier Moranne14Albert Sotto15Albert Sotto16Robert Sabatier17Pascale Fabbro18Thierry Vincent19Thierry Vincent20Catherine Dunyach-Remy21Audrey Winter22Jacques Reynes23Jacques Reynes24Jacques Reynes25Jean-Philippe Lavigne26Pierre Corbeau27Pierre Corbeau28Pierre Corbeau29Institute of Human Genetics, CNRS-Montpellier University, UMR9002, Montpellier, FranceInstitute of Human Genetics, CNRS-Montpellier University, UMR9002, Montpellier, FranceInfectious Diseases Department, University Hospital, Montpellier, FranceInstitute for Functional Genomics, Montpellier University, UMR5203, Montpellier, FranceImmunology Department, University Hospital, Nîmes, FranceInstitute of Human Genetics, CNRS-Montpellier University, UMR9002, Montpellier, FranceImmunology Department, University Hospital, Montpellier, FranceInfectious Diseases Department, University Hospital, Montpellier, FranceInfectious Diseases Department, University Hospital, Montpellier, FranceInfectious Diseases Department, University Hospital, Montpellier, FranceInfectious Diseases Department, University Hospital, Montpellier, FranceIRD UMI 233, INSERM U1175, Montpellier University, Montpellier, FranceMontpellier University, Montpellier, FranceInfectious Diseases Department, University Hospital, Nîmes, FranceNephrology Department, University Hospital, Nîmes, FranceMontpellier University, Montpellier, FranceInfectious Diseases Department, University Hospital, Nîmes, FranceInstitute for Functional Genomics, Montpellier University, UMR5203, Montpellier, France0Medical Informatics Department, University Hospital, Nîmes, FranceImmunology Department, University Hospital, Montpellier, FranceMontpellier University, Montpellier, France1U1047, INSERM, Microbiology University Hospital Nîmes, Montpellier University, Nîmes, FranceInstitute of Human Genetics, CNRS-Montpellier University, UMR9002, Montpellier, FranceInfectious Diseases Department, University Hospital, Montpellier, FranceIRD UMI 233, INSERM U1175, Montpellier University, Montpellier, FranceMontpellier University, Montpellier, France1U1047, INSERM, Microbiology University Hospital Nîmes, Montpellier University, Nîmes, FranceInstitute of Human Genetics, CNRS-Montpellier University, UMR9002, Montpellier, FranceImmunology Department, University Hospital, Nîmes, FranceMontpellier University, Montpellier, FrancePersistent immune activation in virologically suppressed HIV-1 patients, which may be the consequence of various factors including microbial translocation, is a major cause of comorbidities. We have previously shown that different profiles of immune activation may be distinguished in virological responders. Here, we tested the hypothesis that a particular profile might be the consequence of microbial translocation. To this aim, we measured 64 soluble and cell surface markers of inflammation and CD4+ and CD8+ T-cell, B cell, monocyte, NK cell, and endothelial activation in 140 adults under efficient antiretroviral therapy, and classified patients and markers using a double hierarchical clustering analysis. We also measured the plasma levels of the microbial translocation markers bacterial DNA, lipopolysaccharide binding protein (LBP), intestinal-fatty acid binding protein, and soluble CD14. We identified five different immune activation profiles. Patients with an immune activation profile characterized by a high percentage of CD38+CD8+ T-cells and a high level of the endothelial activation marker soluble Thrombomodulin, presented with higher LBP mean (± SEM) concentrations (33.3 ± 1.7 vs. 28.7 ± 0.9 μg/mL, p = 0.025) than patients with other profiles. Our data are consistent with the hypothesis that the immune activation profiles we described are the result of different etiological factors. We propose a model, where particular causes of immune activation, as microbial translocation, drive particular immune activation profiles responsible for particular comorbidities.https://www.frontiersin.org/article/10.3389/fimmu.2019.02185/fullbacterial translocationcell activationinflammationcoagulationendothelium |
| spellingShingle | Mehwish Younas Christina Psomas Christina Psomas Christelle Reynes Renaud Cezar Lucy Kundura Pierre Portales Corinne Merle Nadine Atoui Céline Fernandez Vincent Le Moing Vincent Le Moing Vincent Le Moing Claudine Barbuat Olivier Moranne Albert Sotto Albert Sotto Robert Sabatier Pascale Fabbro Thierry Vincent Thierry Vincent Catherine Dunyach-Remy Audrey Winter Jacques Reynes Jacques Reynes Jacques Reynes Jean-Philippe Lavigne Pierre Corbeau Pierre Corbeau Pierre Corbeau Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia Frontiers in Immunology bacterial translocation cell activation inflammation coagulation endothelium |
| title | Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia |
| title_full | Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia |
| title_fullStr | Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia |
| title_full_unstemmed | Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia |
| title_short | Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia |
| title_sort | microbial translocation is linked to a specific immune activation profile in hiv 1 infected adults with suppressed viremia |
| topic | bacterial translocation cell activation inflammation coagulation endothelium |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02185/full |
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