Mini-puberty testosterone and infant autistic traits
BackgroundLevels of steroid hormones in the first three months of life, a period referred to as ‘mini-puberty’, are one of the earliest physiological differences between typical males and females postnatally. Autistic traits also show consistent typical sex differences in later infancy, after the 18...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1126023/full |
| _version_ | 1797852219173765120 |
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| author | Alex Tsompanidis Sarah Hampton Ezra Aydin Carrie Allison Rosemary Holt Simon Baron-Cohen |
| author_facet | Alex Tsompanidis Sarah Hampton Ezra Aydin Carrie Allison Rosemary Holt Simon Baron-Cohen |
| author_sort | Alex Tsompanidis |
| collection | DOAJ |
| description | BackgroundLevels of steroid hormones in the first three months of life, a period referred to as ‘mini-puberty’, are one of the earliest physiological differences between typical males and females postnatally. Autistic traits also show consistent typical sex differences in later infancy, after the 18th month of life. Previous studies have shown prenatal testosterone is associated with later levels of autistic traits. Studies testing if postnatal testosterone levels are associated with autistic traits have reported null results. No studies to date have investigated mini-puberty longitudinally or tested for interactions with baseline sex differences or familial likelihood of autism.MethodsThe ‘Cambridge Human Imaging and Longitudinal Development Study’ (CHILD) is a prospective enriched cohort study in Cambridge, UK. It includes physiological measurements in early infancy, as well as neurodevelopmental follow-ups over the first two years of life. A subset of the cohort also includes children with a family history of autism (a diagnosed parent or sibling). Salivary testosterone levels were assessed at two time-points, just after the 2nd and 6th month of life. Autistic traits were measured using the Quantitative Checklist of Autism in Toddlers (Q-CHAT) when the children were 18 months of age.ResultsSalivary testosterone levels were significantly higher during ‘mini-puberty’ in the 2nd and 3rd month of life, compared to after the 6th month of life, in both males and females. There was no significant sex difference at either time-point. Log-transformed testosterone levels were not associated with autistic traits (Q-CHAT). There was no interaction effect with infant sex, autism family history or baseline testosterone levels after mini-puberty (at >6 months of age).ConclusionBoth male and female infants have elevated levels of salivary testosterone during mini-puberty but in this relatively small sample this was not associated with their later autistic traits at 18 months or their family history of autism. This suggests that prenatal rather than postnatal testosterone levels are more relevant for understanding the causes of autism. Future studies should test these relationships in larger samples. |
| first_indexed | 2024-04-09T19:30:29Z |
| format | Article |
| id | doaj.art-eab14312071f4daf8e43ea360ed5399e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T19:30:29Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-eab14312071f4daf8e43ea360ed5399e2023-04-05T04:25:29ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11260231126023Mini-puberty testosterone and infant autistic traitsAlex Tsompanidis0Sarah Hampton1Ezra Aydin2Carrie Allison3Rosemary Holt4Simon Baron-Cohen5Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United KingdomYork Trials Unit, University of York, York, United KingdomVagelos College of Physicians and Surgeons, Columbia University, New York, NY, United StatesAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United KingdomAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United KingdomAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United KingdomBackgroundLevels of steroid hormones in the first three months of life, a period referred to as ‘mini-puberty’, are one of the earliest physiological differences between typical males and females postnatally. Autistic traits also show consistent typical sex differences in later infancy, after the 18th month of life. Previous studies have shown prenatal testosterone is associated with later levels of autistic traits. Studies testing if postnatal testosterone levels are associated with autistic traits have reported null results. No studies to date have investigated mini-puberty longitudinally or tested for interactions with baseline sex differences or familial likelihood of autism.MethodsThe ‘Cambridge Human Imaging and Longitudinal Development Study’ (CHILD) is a prospective enriched cohort study in Cambridge, UK. It includes physiological measurements in early infancy, as well as neurodevelopmental follow-ups over the first two years of life. A subset of the cohort also includes children with a family history of autism (a diagnosed parent or sibling). Salivary testosterone levels were assessed at two time-points, just after the 2nd and 6th month of life. Autistic traits were measured using the Quantitative Checklist of Autism in Toddlers (Q-CHAT) when the children were 18 months of age.ResultsSalivary testosterone levels were significantly higher during ‘mini-puberty’ in the 2nd and 3rd month of life, compared to after the 6th month of life, in both males and females. There was no significant sex difference at either time-point. Log-transformed testosterone levels were not associated with autistic traits (Q-CHAT). There was no interaction effect with infant sex, autism family history or baseline testosterone levels after mini-puberty (at >6 months of age).ConclusionBoth male and female infants have elevated levels of salivary testosterone during mini-puberty but in this relatively small sample this was not associated with their later autistic traits at 18 months or their family history of autism. This suggests that prenatal rather than postnatal testosterone levels are more relevant for understanding the causes of autism. Future studies should test these relationships in larger samples.https://www.frontiersin.org/articles/10.3389/fendo.2023.1126023/fullautismmini-pubertytestosteroneinfantautistic traitslongitudinal |
| spellingShingle | Alex Tsompanidis Sarah Hampton Ezra Aydin Carrie Allison Rosemary Holt Simon Baron-Cohen Mini-puberty testosterone and infant autistic traits Frontiers in Endocrinology autism mini-puberty testosterone infant autistic traits longitudinal |
| title | Mini-puberty testosterone and infant autistic traits |
| title_full | Mini-puberty testosterone and infant autistic traits |
| title_fullStr | Mini-puberty testosterone and infant autistic traits |
| title_full_unstemmed | Mini-puberty testosterone and infant autistic traits |
| title_short | Mini-puberty testosterone and infant autistic traits |
| title_sort | mini puberty testosterone and infant autistic traits |
| topic | autism mini-puberty testosterone infant autistic traits longitudinal |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1126023/full |
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