The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.
Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-11-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2987804?pdf=render |
| _version_ | 1811274428853518336 |
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| author | Helen Waller-Evans Simone Prömel Tobias Langenhan John Dixon Dirk Zahn William H Colledge Joanne Doran Mark B L Carlton Ben Davies Samuel A J R Aparicio Johannes Grosse Andreas P Russ |
| author_facet | Helen Waller-Evans Simone Prömel Tobias Langenhan John Dixon Dirk Zahn William H Colledge Joanne Doran Mark B L Carlton Ben Davies Samuel A J R Aparicio Johannes Grosse Andreas P Russ |
| author_sort | Helen Waller-Evans |
| collection | DOAJ |
| description | Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates, but the function of most of these receptors is still not understood. The orphan Adhesion-GPCR GPR126 has recently been shown to play an essential role in the myelination of peripheral nerves in zebrafish. In parallel, whole-genome association studies have implicated variation at the GPR126 locus as a determinant of body height in the human population. The physiological function of GPR126 in mammals is still unknown. We describe a targeted mutation of GPR126 in the mouse, and show that GPR126 is required for embryonic viability and cardiovascular development. |
| first_indexed | 2024-04-12T23:18:52Z |
| format | Article |
| id | doaj.art-eab20159ed9b4373891dcff391e52753 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T23:18:52Z |
| publishDate | 2010-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eab20159ed9b4373891dcff391e527532022-12-22T03:12:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-11-01511e1404710.1371/journal.pone.0014047The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.Helen Waller-EvansSimone PrömelTobias LangenhanJohn DixonDirk ZahnWilliam H ColledgeJoanne DoranMark B L CarltonBen DaviesSamuel A J R AparicioJohannes GrosseAndreas P RussAdhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates, but the function of most of these receptors is still not understood. The orphan Adhesion-GPCR GPR126 has recently been shown to play an essential role in the myelination of peripheral nerves in zebrafish. In parallel, whole-genome association studies have implicated variation at the GPR126 locus as a determinant of body height in the human population. The physiological function of GPR126 in mammals is still unknown. We describe a targeted mutation of GPR126 in the mouse, and show that GPR126 is required for embryonic viability and cardiovascular development.http://europepmc.org/articles/PMC2987804?pdf=render |
| spellingShingle | Helen Waller-Evans Simone Prömel Tobias Langenhan John Dixon Dirk Zahn William H Colledge Joanne Doran Mark B L Carlton Ben Davies Samuel A J R Aparicio Johannes Grosse Andreas P Russ The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS ONE |
| title | The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. |
| title_full | The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. |
| title_fullStr | The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. |
| title_full_unstemmed | The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. |
| title_short | The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. |
| title_sort | orphan adhesion gpcr gpr126 is required for embryonic development in the mouse |
| url | http://europepmc.org/articles/PMC2987804?pdf=render |
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