A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting
The past a few decades have seen exponential growth in the field of regenerative medicine. What began as extirpative (complete tissue or organ removal), with little regard to the effects of tissue loss and/or disfigurement, has evolved towards fabricating engineered tissues using personalized living...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/4/239 |
| _version_ | 1797434665102999552 |
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| author | Matangi Parimala Chelvi Ratnamani Xinping Zhang Hongjun Wang |
| author_facet | Matangi Parimala Chelvi Ratnamani Xinping Zhang Hongjun Wang |
| author_sort | Matangi Parimala Chelvi Ratnamani |
| collection | DOAJ |
| description | The past a few decades have seen exponential growth in the field of regenerative medicine. What began as extirpative (complete tissue or organ removal), with little regard to the effects of tissue loss and/or disfigurement, has evolved towards fabricating engineered tissues using personalized living cells (e.g., stem cells), and customizing a matrix or structural organization to support and guide tissue development. Biofabrication, largely accomplished through three-dimensional (3D) printing technology, provides precise, controlled, and layered assemblies of cells and biomaterials, emulating the heterogenous microenvironment of the in vivo tissue architecture. This review provides a concise framework for the bio-manufacturing process and addresses the contributions of hydrogels to biological modeling. The versatility of hydrogels in bioprinting is detailed along with an extensive elaboration of their physical, mechanical, and biological properties, as well as their assets and limitations in bioprinting. The scope of various hydrogels in tissue formation has been discussed through the case studies of biofabricated 3D constructs in order to provide the readers with a glimpse into the barrier-breaking accomplishments of biomedical sciences. In the end, the restraints of bioprinting itself are discussed, accompanied with the identification of available engineering strategies to overcome them. |
| first_indexed | 2024-03-09T10:36:46Z |
| format | Article |
| id | doaj.art-eab24f5614f146a3826459ce4102029d |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T10:36:46Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-eab24f5614f146a3826459ce4102029d2023-12-01T20:56:08ZengMDPI AGGels2310-28612022-04-018423910.3390/gels8040239A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based BioprintingMatangi Parimala Chelvi Ratnamani0Xinping Zhang1Hongjun Wang2Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USADepartment of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USADepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USAThe past a few decades have seen exponential growth in the field of regenerative medicine. What began as extirpative (complete tissue or organ removal), with little regard to the effects of tissue loss and/or disfigurement, has evolved towards fabricating engineered tissues using personalized living cells (e.g., stem cells), and customizing a matrix or structural organization to support and guide tissue development. Biofabrication, largely accomplished through three-dimensional (3D) printing technology, provides precise, controlled, and layered assemblies of cells and biomaterials, emulating the heterogenous microenvironment of the in vivo tissue architecture. This review provides a concise framework for the bio-manufacturing process and addresses the contributions of hydrogels to biological modeling. The versatility of hydrogels in bioprinting is detailed along with an extensive elaboration of their physical, mechanical, and biological properties, as well as their assets and limitations in bioprinting. The scope of various hydrogels in tissue formation has been discussed through the case studies of biofabricated 3D constructs in order to provide the readers with a glimpse into the barrier-breaking accomplishments of biomedical sciences. In the end, the restraints of bioprinting itself are discussed, accompanied with the identification of available engineering strategies to overcome them.https://www.mdpi.com/2310-2861/8/4/2393D bioprintingliving cellshydrogel matrixlayer-by-layer assemblagehydrogel characterizationbioprinting limitation |
| spellingShingle | Matangi Parimala Chelvi Ratnamani Xinping Zhang Hongjun Wang A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting Gels 3D bioprinting living cells hydrogel matrix layer-by-layer assemblage hydrogel characterization bioprinting limitation |
| title | A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting |
| title_full | A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting |
| title_fullStr | A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting |
| title_full_unstemmed | A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting |
| title_short | A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting |
| title_sort | comprehensive assessment on the pivotal role of hydrogels in scaffold based bioprinting |
| topic | 3D bioprinting living cells hydrogel matrix layer-by-layer assemblage hydrogel characterization bioprinting limitation |
| url | https://www.mdpi.com/2310-2861/8/4/239 |
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