New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis

New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axonal projections, which rely on the integrity of neuronal cytoskeleton and mitochondria to r...

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Bibliographic Details
Main Authors: Frances Theunissen, Phillip K. West, Samuel Brennan, Bojan Petrović, Kosar Hooshmand, P. Anthony Akkari, Matt Keon, Boris Guennewig
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Translational Neurodegeneration
Subjects:
Cytoskeleton
Neurofilament
Mitochondria
Amyotrophic lateral sclerosis
Neurodegeneration
Axonal transport
Online Access:https://doi.org/10.1186/s40035-021-00272-z

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