Amino acid substitutions in human growth hormone affect secondary structure and receptor binding.

Amino acid substitutions in human growth hormone affect secondary structure and receptor binding.

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The interaction between human Growth Hormone (hGH) and hGH Receptor (hGHR) has basic relevance to cancer and growth disorders, and hGH is the scaffold for Pegvisomant, an anti-acromegaly therapeutic. For the latter reason, hGH has been extensively engineered by early workers to improve binding and o...

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Bibliographic Details
Main Authors: Andrei Rajkovic, Sandesh Kanchugal, Eldar Abdurakhmanov, Rebecca Howard, Sebastian Wärmländer, Joseph Erwin, Hugo A Barrera Saldaña, Astrid Gräslund, Helena Danielson, Samuel Coulbourn Flores
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0282741

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