Anti-Lymphoma Efficacy Comparison of Anti-Cd20 Monoclonal Antibody-Targeted and Non-Targeted Star-Shaped Polymer-Prodrug Conjugates

Anti-Lymphoma Efficacy Comparison of Anti-Cd20 Monoclonal Antibody-Targeted and Non-Targeted Star-Shaped Polymer-Prodrug Conjugates

Here we describe the synthesis and biological properties of two types of star-shaped polymer-doxorubicin conjugates: non-targeted conjugate prepared as long-circulating high-molecular-weight (HMW) polymer prodrugs with a dendrimer core and a targeted conjugate with the anti-CD20 monoclonal antibody...

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Bibliographic Details
Main Authors: Ondřej Lidický, Olga Janoušková, Jiří Strohalm, Mahmudul Alam, Pavel Klener, Tomáš Etrych
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Molecules
Subjects:
HPMA copolymers
drug delivery systems
doxorubicin
monoclonal antibody
drug targeting
Online Access:http://www.mdpi.com/1420-3049/20/11/19664

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