Improvement of Depressed Mood with Green Tea Intake
Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the bi...
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MDPI AG
2022-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/14/2949 |
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| author | Keiko Unno Daisuke Furushima Yuya Tanaka Takeichiro Tominaga Hirotomo Nakamura Hiroshi Yamada Kyoko Taguchi Toshinao Goda Yoriyuki Nakamura |
| author_facet | Keiko Unno Daisuke Furushima Yuya Tanaka Takeichiro Tominaga Hirotomo Nakamura Hiroshi Yamada Kyoko Taguchi Toshinao Goda Yoriyuki Nakamura |
| author_sort | Keiko Unno |
| collection | DOAJ |
| description | Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the biological stress response and inflammation in the brain. Regarding the stress reduction effect of green tea, we found that the sum of caffeine (C) and epigallocatechin gallate (E) relative to the sum of theanine (T) and arginine (A), the major components of green tea, or the CE/TA ratio, is important. The results showed that depression-like behavior, adrenal hypertrophy as a typical stress response, and brain inflammation were suppressed in mice fed green tea components with CE/TA ratios of 2 to 8. In addition, the expression of <i>Npas4</i>, which is reduced in anxiety and depression, was maintained at the same level as controls in mice that consumed green tea with a CE/TA ratio of 4. In clinical human trials, the consumption of green tea with CE/TA ratios of 3.9 and 4.7 reduced susceptibility to subjective depression. These results suggest that the daily consumption of green tea with a CE/TA ratio of 4–5 is beneficial to improving depressed mood. |
| first_indexed | 2024-03-09T06:05:49Z |
| format | Article |
| id | doaj.art-eab76cc557f24544b0bd8d2df2d1cd67 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T06:05:49Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-eab76cc557f24544b0bd8d2df2d1cd672023-12-03T12:04:45ZengMDPI AGNutrients2072-66432022-07-011414294910.3390/nu14142949Improvement of Depressed Mood with Green Tea IntakeKeiko Unno0Daisuke Furushima1Yuya Tanaka2Takeichiro Tominaga3Hirotomo Nakamura4Hiroshi Yamada5Kyoko Taguchi6Toshinao Goda7Yoriyuki Nakamura8Tea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanDepartment of Drug Evaluation & Informatics Graduate School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422-8526, JapanDepartment of Drug Evaluation & Informatics Graduate School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422-8526, JapanDepartment of Drug Evaluation & Informatics Graduate School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422-8526, JapanDepartment of Drug Evaluation & Informatics Graduate School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422-8526, JapanDepartment of Drug Evaluation & Informatics Graduate School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422-8526, JapanTea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanFaculty of Food and Nutritional Sciences, University of Shizuoka, Shizuoka 422-8526, JapanTea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanBeing in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the biological stress response and inflammation in the brain. Regarding the stress reduction effect of green tea, we found that the sum of caffeine (C) and epigallocatechin gallate (E) relative to the sum of theanine (T) and arginine (A), the major components of green tea, or the CE/TA ratio, is important. The results showed that depression-like behavior, adrenal hypertrophy as a typical stress response, and brain inflammation were suppressed in mice fed green tea components with CE/TA ratios of 2 to 8. In addition, the expression of <i>Npas4</i>, which is reduced in anxiety and depression, was maintained at the same level as controls in mice that consumed green tea with a CE/TA ratio of 4. In clinical human trials, the consumption of green tea with CE/TA ratios of 3.9 and 4.7 reduced susceptibility to subjective depression. These results suggest that the daily consumption of green tea with a CE/TA ratio of 4–5 is beneficial to improving depressed mood.https://www.mdpi.com/2072-6643/14/14/2949argininecaffeinecatechinhypothalamus-pituitary-adrenal axisinflammationlipopolysaccharide |
| spellingShingle | Keiko Unno Daisuke Furushima Yuya Tanaka Takeichiro Tominaga Hirotomo Nakamura Hiroshi Yamada Kyoko Taguchi Toshinao Goda Yoriyuki Nakamura Improvement of Depressed Mood with Green Tea Intake Nutrients arginine caffeine catechin hypothalamus-pituitary-adrenal axis inflammation lipopolysaccharide |
| title | Improvement of Depressed Mood with Green Tea Intake |
| title_full | Improvement of Depressed Mood with Green Tea Intake |
| title_fullStr | Improvement of Depressed Mood with Green Tea Intake |
| title_full_unstemmed | Improvement of Depressed Mood with Green Tea Intake |
| title_short | Improvement of Depressed Mood with Green Tea Intake |
| title_sort | improvement of depressed mood with green tea intake |
| topic | arginine caffeine catechin hypothalamus-pituitary-adrenal axis inflammation lipopolysaccharide |
| url | https://www.mdpi.com/2072-6643/14/14/2949 |
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