Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats

Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats

A combination of the tyrosine kinase inhibitor—sorafenib—and the opioid analgesic—morphine—can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration may affect their pharmacokinetics, and...

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Bibliographic Details
Main Authors: Agnieszka Karbownik, Danuta Szkutnik-Fiedler, Tomasz Grabowski, Anna Wolc, Joanna Stanisławiak-Rudowicz, Radosław Jaźwiec, Edmund Grześkowiak, Edyta Szałek
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
pharmacokinetics
drug–drug interaction
sorafenib
sorafenib N-oxide
morphine
Online Access:https://www.mdpi.com/1999-4923/13/12/2172

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