Serum Markers of Inflammation Mediate the Positive Association Between Neuroticism and Depression

Serum Markers of Inflammation Mediate the Positive Association Between Neuroticism and Depression

Background: The personality trait neuroticism has been implicated in a poor response to stress, may relate to increased concentrations of cytokines and the development of depression. Inflammatory mechanisms may also be associated with the onset, severity and symptoms of depression. Both are related...

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Bibliographic Details
Main Authors: Frank M. Schmidt, Christian Sander, Juliane Minkwitz, Roland Mergl, Bethan Dalton, Lesca M. Holdt, Daniel Teupser, Ulrich Hegerl, Hubertus Himmerich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Psychiatry
Subjects:
neuroticism
depression
chronic stress
cytokines
TNF-α
mediation analyses
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00609/full

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