Assessment of CAR-T Cell-Mediated Cytotoxicity in 3D Microfluidic Cancer Co-Culture Models for Combination Therapy

Assessment of CAR-T Cell-Mediated Cytotoxicity in 3D Microfluidic Cancer Co-Culture Models for Combination Therapy

Chimeric antigen receptor (CAR)-T cell therapy is efficacious against many haematological malignancies, but challenges remain when using this cellular immunotherapy for treating solid tumours. Classical 2D <italic>in vitro</italic> models fail to recapitulate the complexity of the tumour...

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Bibliographic Details
Main Authors: Karla Paterson, Sarah Paterson, Theresa Mulholland, Seth B. Coffelt, Michele Zagnoni
Format: Article
Language:English
Published: IEEE 2022-01-01
Series:IEEE Open Journal of Engineering in Medicine and Biology
Subjects:
Immunotherapy
lab-on-a-chip
solid tumour microenvironment
three-dimensional in vitro complex model
Online Access:https://ieeexplore.ieee.org/document/9783024/

Internet

https://ieeexplore.ieee.org/document/9783024/

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