Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM?
Abstract Background Thymoma is a type of rare mediastinal tumor whose clinical characteristics and indicators of prognosis are poorly understood. This single‐institution retrospective study aimed to assess the predictive value of tumor, node, metastasis (TNM) staging incorporating tumor size in pred...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14255 |
| _version_ | 1798017140684488704 |
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| author | Yen‐Chiang Tseng Han‐Shui Hsu Yi‐Hsuan Lin Yen‐Han Tseng Chih‐Wen Shu Yih‐Gang Goan Ching‐Jiunn Tseng |
| author_facet | Yen‐Chiang Tseng Han‐Shui Hsu Yi‐Hsuan Lin Yen‐Han Tseng Chih‐Wen Shu Yih‐Gang Goan Ching‐Jiunn Tseng |
| author_sort | Yen‐Chiang Tseng |
| collection | DOAJ |
| description | Abstract Background Thymoma is a type of rare mediastinal tumor whose clinical characteristics and indicators of prognosis are poorly understood. This single‐institution retrospective study aimed to assess the predictive value of tumor, node, metastasis (TNM) staging incorporating tumor size in predicting the risk of thymoma recurrence after resection. Methods Four binary logistic regression models were developed. Models I and II included median tumor size and TNM stage, respectively. Model III included the above two variables. Model IV was model III containing these two variables and their interaction terms. All models were adjusted for WHO histological type, operational time, and adjuvant therapy. Results A total of 276 patients with a median age of 51.0, including 21 patients with thymoma recurrence, were included in this study. Models II or III showed a lower ‐2LogL and higher AUC (0.735 and 0.738 vs. 0.576) with significantly better discrimination than model I, and model III and model II shared similar discrimination. In model III, TNM stage was positively correlated with thymoma recurrence. The recurrence risk of patients with TNM stage IV was significantly higher than those with TNM stage I (OR of 11.03, p = 0.022). No significant correlation between the tumor size and recurrence risk (p = 0.779) and no interaction was found between medium tumor size and TNM stage in model IV. Conclusions This study suggests that the prediction contribution of the TNM stage combined with tumor size is similar to the TNM stage alone for tumor recurrence in patients with thymoma after surgical resection. |
| first_indexed | 2024-04-11T16:02:02Z |
| format | Article |
| id | doaj.art-eabbe20f7d884ac2841378c7c2a58be7 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-11T16:02:02Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-eabbe20f7d884ac2841378c7c2a58be72022-12-22T04:14:58ZengWileyThoracic Cancer1759-77061759-77142022-02-0113334635210.1111/1759-7714.14255Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM?Yen‐Chiang Tseng0Han‐Shui Hsu1Yi‐Hsuan Lin2Yen‐Han Tseng3Chih‐Wen Shu4Yih‐Gang Goan5Ching‐Jiunn Tseng6Division of Thoracic Surgery, Department of Surgery Kaohsiung Veterans General Hospital Kaohsiung TaiwanDivision of Thoracic Surgery, Department of Surgery Taipei Veterans General Hospital Taipei TaiwanDepartment of Family Medicine, School of Medicine National Yang‐Ming University Taipei TaiwanSchool of Medicine, National Yang‐Ming University Taipei TaiwanInstitute of Biopharmaceutical Sciences, National Sun Yat‐Sen University Kaohsiung TaiwanDivision of Thoracic Surgery, Department of Surgery Kaohsiung Veterans General Hospital Kaohsiung TaiwanInstitute of Clinical Medicine, National Yang‐Ming University Taipei TaiwanAbstract Background Thymoma is a type of rare mediastinal tumor whose clinical characteristics and indicators of prognosis are poorly understood. This single‐institution retrospective study aimed to assess the predictive value of tumor, node, metastasis (TNM) staging incorporating tumor size in predicting the risk of thymoma recurrence after resection. Methods Four binary logistic regression models were developed. Models I and II included median tumor size and TNM stage, respectively. Model III included the above two variables. Model IV was model III containing these two variables and their interaction terms. All models were adjusted for WHO histological type, operational time, and adjuvant therapy. Results A total of 276 patients with a median age of 51.0, including 21 patients with thymoma recurrence, were included in this study. Models II or III showed a lower ‐2LogL and higher AUC (0.735 and 0.738 vs. 0.576) with significantly better discrimination than model I, and model III and model II shared similar discrimination. In model III, TNM stage was positively correlated with thymoma recurrence. The recurrence risk of patients with TNM stage IV was significantly higher than those with TNM stage I (OR of 11.03, p = 0.022). No significant correlation between the tumor size and recurrence risk (p = 0.779) and no interaction was found between medium tumor size and TNM stage in model IV. Conclusions This study suggests that the prediction contribution of the TNM stage combined with tumor size is similar to the TNM stage alone for tumor recurrence in patients with thymoma after surgical resection.https://doi.org/10.1111/1759-7714.14255thymomaTNM staging systemtumor size |
| spellingShingle | Yen‐Chiang Tseng Han‐Shui Hsu Yi‐Hsuan Lin Yen‐Han Tseng Chih‐Wen Shu Yih‐Gang Goan Ching‐Jiunn Tseng Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM? Thoracic Cancer thymoma TNM staging system tumor size |
| title | Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM? |
| title_full | Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM? |
| title_fullStr | Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM? |
| title_full_unstemmed | Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM? |
| title_short | Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM? |
| title_sort | does size affect the prognosis of resectable thymoma beyond the eighth edition tnm |
| topic | thymoma TNM staging system tumor size |
| url | https://doi.org/10.1111/1759-7714.14255 |
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