Aflibercept for long-term treatment of diabetic macular edema and proliferative diabetic retinopathy: a meta-analysis

Aflibercept for long-term treatment of diabetic macular edema and proliferative diabetic retinopathy: a meta-analysis

PurposeThis meta-analysis compared the long-term (12 months or 24 months) efficacy and safety of intravitreal aflibercept injection (IAI) for diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR).MethodsWe selected 16 randomized controlled trials (RCTs) performed after 2015 that...

Full description

Bibliographic Details
Main Authors:	Xiao Xie, Chao Lian, Zhiping Zhang, Meng Feng, Wenqi Wang, Xiaomeng Yuan, Yanmei Shi, Tingting Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Series:	Frontiers in Endocrinology
Subjects:	diabetic macular edema proliferative diabetic retinopathy aflibercept meta-analysis anti-vascular endothelial growth factor focal/grid laser photocoagulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1144422/full

Similar Items

Retinal vein changes after treatment with aflibercept and PRP in high-risk proliferative diabetic retinopathy
by: Hui Zhao, et al.
Published: (2023-03-01)

Aflibercept 5+PRN with retinal laser photocoagulation is more effective than retinal laser photocoagulation alone and aflibercept 3+PRN with retinal laser photocoagulation in patients with high-risk proliferative diabetic retinopathy and diabetic macular edema: a 12-month clinical trial
by: Shuting Li, et al.
Published: (2024-02-01)

Ultrastructural features of epiretinal membranes after intravitreal injection of various doses of aflibercept in patients with proliferative diabetic retinopathy
by: Vira S. Ponomarchuk, et al.
Published: (2021-12-01)

Intravitreal aflibercept compared with panretinal photocoagulation for proliferative diabetic retinopathy: the CLARITY non-inferiority RCT
by: Sobha Sivaprasad, et al.
Published: (2018-10-01)

Differences in aqueous humor protein profiles in patients with proliferative diabetic retinopathy before and after aflibercept treatment
by: Tan Wang, et al.
Published: (2024-01-01)

Features of aflibercept plus hyperbaric oxygen therapy for diabetic macular edema
by: V. O. Drozdov, et al.
Published: (2022-08-01)

Outcomes of aflibercept for post-vitrectomy vitreous hemorrhage in patients with proliferative diabetic retinopathy
by: O. O. Putienko, et al.
Published: (2021-06-01)

Treatment of proliferative diabetic retinopathy by vitrectomy combined with retinal photocoagulation
by: Jun Jia, et al.
Published: (2014-05-01)

Efficacy of the modified staged method of surgical treatment for proliferative diabetic retinopathy
by: Vira S Ponomarchuk, et al.
Published: (2022-03-01)

Efficacy of Aflibercept versus Ranibizumab in the treatment of diabetic macular edema
by: Xiu-Xian Wang, et al.
Published: (2021-12-01)

Role of peripheral pan-retinal photocoagulation in diabetic macular edema treated with intravitreal ziv-aflibercept
by: Mansour AM, et al.
Published: (2019-04-01)

Pattern scan laser versus single spot laser in panretinal photocoagulation treatment for proliferative diabetic retinopathy
by: Shu Zhang, et al.
Published: (2017-02-01)

Aflibercept compared with dexamethasone in diabetic macular edema
by: Rodolfo Garretón, et al.
Published: (2021-05-01)

Incidence and Sequelae of Macular Edema Post Pan-retinal Photocoagulation for Proliferative Diabetic Retinopathy
by: Hebatalla S Makled, et al.
Published: (2023-01-01)

Vascular endothelial growth factor inhibition and proliferative diabetic retinopathy, a changing treatment paradigm?
by: Lihteh Wu, et al.
Published: (2019-01-01)

Clinical research on laser therapy and Ranibizumab for proliferative diabetic retinopathy
by: Hong Zou, et al.
Published: (2016-01-01)

Intravitreal Injection for Diabetic Macular Edema as Adjunctive Therapy for Proliferative Diabetic Retinopathy: A Retrospective Study
by: Aljundi W, et al.
Published: (2022-01-01)

Effect of panretinal photocoagulation combined with intravitreal Conbercept in the treatment of proliferative diabetic retinopathy with different stages
by: Tian-Hui Shan, et al.
Published: (2023-08-01)

The efficacy and safety of aflibercept and conbercept in diabetic macular edema
by: Cai S, et al.
Published: (2018-10-01)

Curative effect of 25G vitrectomy combined with different anti-VEGF drugs on proliferative diabetic retinopathy
by: Yan-Xia Shang, et al.
Published: (2022-11-01)

Effect of intravitreal aflibercept on recalcitrant diabetic macular edema
by: Kendra A. Klein, et al.
Published: (2017-04-01)

Observation of improved extra panretinal photocoagulation for high risk proliferative diabetic retinopathy
by: Shi-Xin Qi, et al.
Published: (2016-07-01)

Curative effect of extra-panretinal photocoagulation on proliferative diabetic retinopathy during vitreous operation
by: Hao-Fei Zhao, et al.
Published: (2018-04-01)

Temporal Trends in the Treatment of Proliferative Diabetic Retinopathy
by: Dan Gong, MD, et al.
Published: (2021-09-01)

Sub-panretinal photocoagulation <i>vs</i> panretinal photocoagulation for pre-proliferative diabetic retinopathy: a prospective non-randomized study
by: Li Wang, et al.
Published: (2016-03-01)

Vitrectomy for proliferative diabetic retinopathy
by: Chao Peng, et al.
Published: (2013-10-01)

Low Luminance Visual Acuity and Low Luminance Deficit in Proliferative Diabetic Retinopathy
by: Eleni Karatsai, et al.
Published: (2021-01-01)

ANGIOGENESIS IN PROLIFERATIVE DIABETIC RETINOPATHY: RERSPECTIVES OF ANTI-VEGF THERAPY (REVIEW OF LITERATURE)
by: V. I. Konenkov, et al.
Published: (2015-12-01)

Determining the Superiority of Vitrectomy vs Aflibercept for Treating Dense Diabetic Vitreous Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
by: Quiroz-Reyes MA, et al.
Published: (2023-08-01)

Long term effect of panretinal photocoagulation on retinal nerve fiber layer parameters in patients with proliferative diabetic retinopathy
by: Meenakshi Wadhwani, et al.
Published: (2019-01-01)

One-Year Outcome of Aflibercept Intravitreal Injection in Vitrectomized Eyes with Diabetic Macular Edema
by: Tran THC, et al.
Published: (2021-05-01)

One-year results of switching to aflibercept for persistent diabetic macular edema resistant to bevacizumab
by: Mahmoud Alaa Abouhussein, et al.
Published: (2021-01-01)

Effect of Intravitreal Bevacizumab Injection before Panretinal Photocoagulation on the Prevention of Macular Edema Aggravation in Proliferative Diabetic Retinopathy
by: Wungrak Choi, et al.
Published: (2020-11-01)

PLASMA LEVELS OF ANGIOGENIC AND ANGIOSTATIC FACTORS AFTER PANRETINAL PHOTOCOAGULATION FOR PROLIFERATIVE DIABETIC RETINOPATHY
by: Bhaskar Gaonkar
Published: (2020-09-01)

Intravitreal Aflibercept versus Laser Photocoagulation in Asian Patients with Diabetic Macular Edema: The VIVID-East Study
by: Chen YX, et al.
Published: (2020-03-01)

Clinical Application of Intravitreal Aflibercept Injection for Diabetic Macular Edema Comparing Two Loading Regimens
by: Yoo-Ri Chung, et al.
Published: (2023-03-01)

Comparative study between ranibizumab and aflibercept in the management of macular edema caused by diabetes mellitus in age group more than 40 years
by: Abd El-Magid M Tag El-Din
Published: (2019-01-01)

Efficacy and safety of intravitreal aflibercept therapy in diabetic macular edema
by: Ali Cihat Aslan, et al.
Published: (2019-06-01)

Microvascular Changes After Conbercept Intravitreal Injection of PDR With or Without Center-Involved Diabetic Macular Edema Analyzed by OCTA
by: Wei Lin, et al.
Published: (2022-03-01)

Efficacy of Aflibercept and Ranibizumab in the treatment of diabetic macular edema
by: Bing Wu, et al.
Published: (2023-08-01)