Molecular and clinicopathological characteristics of ERBB2 gene fusions in 32,131 Chinese patients with solid tumors

Molecular and clinicopathological characteristics of ERBB2 gene fusions in 32,131 Chinese patients with solid tumors

ERBB2 amplification is one of the most important and mature targets for HER2-targeted drug therapy. Somatic mutations of ERBB2 in the tyrosine kinase domain have been studied extensively, and play a role in response to anti-HER2 therapy among different cancer types. However, ERBB2 fusion has not bee...

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Bibliographic Details
Main Authors: Yin Guan, Yutong Wang, Hongxia Li, Jing Meng, Xia You, Xiaofeng Zhu, Qin Zhang, Tingting Sun, Chuang Qi, Guangyu An, Ying Fan, Binghe Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
next generation sequencing
ERBB2 fusion
HER2
trastuzumab
clinical impact
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.986674/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.986674/full

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