IL-22 signaling contributes to West Nile encephalitis pathogenesis.
The Th17 cytokine, IL-22, regulates host immune responses to extracellular pathogens. Whether IL-22 plays a role in viral infection, however, is poorly understood. We report here that Il22(-/-) mice were more resistant to lethal West Nile virus (WNV) encephalitis, but had similar viral loads in the...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3429482?pdf=render |
| _version_ | 1818178840535498752 |
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| author | Penghua Wang Fengwei Bai Lauren A Zenewicz Jianfeng Dai David Gate Gong Cheng Long Yang Feng Qian Xiaoling Yuan Ruth R Montgomery Richard A Flavell Terrence Town Erol Fikrig |
| author_facet | Penghua Wang Fengwei Bai Lauren A Zenewicz Jianfeng Dai David Gate Gong Cheng Long Yang Feng Qian Xiaoling Yuan Ruth R Montgomery Richard A Flavell Terrence Town Erol Fikrig |
| author_sort | Penghua Wang |
| collection | DOAJ |
| description | The Th17 cytokine, IL-22, regulates host immune responses to extracellular pathogens. Whether IL-22 plays a role in viral infection, however, is poorly understood. We report here that Il22(-/-) mice were more resistant to lethal West Nile virus (WNV) encephalitis, but had similar viral loads in the periphery compared to wild type (WT) mice. Viral loads, leukocyte infiltrates, proinflammatory cytokines and apoptotic cells in the central nervous system (CNS) of Il22(-/-) mice were also strikingly reduced. Further examination showed that Cxcr2, a chemokine receptor that plays a non-redundant role in mediating neutrophil migration, was significantly reduced in Il22(-/-) compared to WT leukocytes. Expression of Cxcr2 ligands, cxcl1 and cxcl5, was lower in Il22(-/-) brains than wild type mice. Correspondingly, neutrophil migration from the blood into the brain was attenuated following lethal WNV infection of Il22(-/-) mice. Our results suggest that IL-22 signaling exacerbates lethal WNV encephalitis likely by promoting WNV neuroinvasion. |
| first_indexed | 2024-12-11T20:54:22Z |
| format | Article |
| id | doaj.art-eabd8fbd9afc49ff9fc8c8c12991499a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T20:54:22Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eabd8fbd9afc49ff9fc8c8c12991499a2022-12-22T00:51:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4415310.1371/journal.pone.0044153IL-22 signaling contributes to West Nile encephalitis pathogenesis.Penghua WangFengwei BaiLauren A ZenewiczJianfeng DaiDavid GateGong ChengLong YangFeng QianXiaoling YuanRuth R MontgomeryRichard A FlavellTerrence TownErol FikrigThe Th17 cytokine, IL-22, regulates host immune responses to extracellular pathogens. Whether IL-22 plays a role in viral infection, however, is poorly understood. We report here that Il22(-/-) mice were more resistant to lethal West Nile virus (WNV) encephalitis, but had similar viral loads in the periphery compared to wild type (WT) mice. Viral loads, leukocyte infiltrates, proinflammatory cytokines and apoptotic cells in the central nervous system (CNS) of Il22(-/-) mice were also strikingly reduced. Further examination showed that Cxcr2, a chemokine receptor that plays a non-redundant role in mediating neutrophil migration, was significantly reduced in Il22(-/-) compared to WT leukocytes. Expression of Cxcr2 ligands, cxcl1 and cxcl5, was lower in Il22(-/-) brains than wild type mice. Correspondingly, neutrophil migration from the blood into the brain was attenuated following lethal WNV infection of Il22(-/-) mice. Our results suggest that IL-22 signaling exacerbates lethal WNV encephalitis likely by promoting WNV neuroinvasion.http://europepmc.org/articles/PMC3429482?pdf=render |
| spellingShingle | Penghua Wang Fengwei Bai Lauren A Zenewicz Jianfeng Dai David Gate Gong Cheng Long Yang Feng Qian Xiaoling Yuan Ruth R Montgomery Richard A Flavell Terrence Town Erol Fikrig IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS ONE |
| title | IL-22 signaling contributes to West Nile encephalitis pathogenesis. |
| title_full | IL-22 signaling contributes to West Nile encephalitis pathogenesis. |
| title_fullStr | IL-22 signaling contributes to West Nile encephalitis pathogenesis. |
| title_full_unstemmed | IL-22 signaling contributes to West Nile encephalitis pathogenesis. |
| title_short | IL-22 signaling contributes to West Nile encephalitis pathogenesis. |
| title_sort | il 22 signaling contributes to west nile encephalitis pathogenesis |
| url | http://europepmc.org/articles/PMC3429482?pdf=render |
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