Chromatin regulates IL-33 release and extracellular cytokine activity
Interleukin-33 (IL-33) can be released as a cytokine or transported into the nucleus, but the significance of this nuclear shuttling is not fully understood. Here the authors show that chromatin-binding of IL-33 alters, unexpectedly, the activity of IL-33 both in alarmin release kinetics and recepto...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05485-x |
| _version_ | 1818425527068786688 |
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| author | Jared Travers Mark Rochman Cora E. Miracle Jeff E. Habel Michael Brusilovsky Julie M. Caldwell Jeffrey K. Rymer Marc E. Rothenberg |
| author_facet | Jared Travers Mark Rochman Cora E. Miracle Jeff E. Habel Michael Brusilovsky Julie M. Caldwell Jeffrey K. Rymer Marc E. Rothenberg |
| author_sort | Jared Travers |
| collection | DOAJ |
| description | Interleukin-33 (IL-33) can be released as a cytokine or transported into the nucleus, but the significance of this nuclear shuttling is not fully understood. Here the authors show that chromatin-binding of IL-33 alters, unexpectedly, the activity of IL-33 both in alarmin release kinetics and receptor signaling capacity. |
| first_indexed | 2024-12-14T14:15:21Z |
| format | Article |
| id | doaj.art-eabe5c744cb94aef8a004eeb291a50d3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:15:21Z |
| publishDate | 2018-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-eabe5c744cb94aef8a004eeb291a50d32022-12-21T22:58:13ZengNature PortfolioNature Communications2041-17232018-08-019111510.1038/s41467-018-05485-xChromatin regulates IL-33 release and extracellular cytokine activityJared Travers0Mark Rochman1Cora E. Miracle2Jeff E. Habel3Michael Brusilovsky4Julie M. Caldwell5Jeffrey K. Rymer6Marc E. Rothenberg7Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical CenterDivision of Allergy and Immunology, Cincinnati Children’s Hospital Medical CenterDivision of Allergy and Immunology, Cincinnati Children’s Hospital Medical CenterDivision of Allergy and Immunology, Cincinnati Children’s Hospital Medical CenterDivision of Allergy and Immunology, Cincinnati Children’s Hospital Medical CenterDivision of Allergy and Immunology, Cincinnati Children’s Hospital Medical CenterDivision of Allergy and Immunology, Cincinnati Children’s Hospital Medical CenterDivision of Allergy and Immunology, Cincinnati Children’s Hospital Medical CenterInterleukin-33 (IL-33) can be released as a cytokine or transported into the nucleus, but the significance of this nuclear shuttling is not fully understood. Here the authors show that chromatin-binding of IL-33 alters, unexpectedly, the activity of IL-33 both in alarmin release kinetics and receptor signaling capacity.https://doi.org/10.1038/s41467-018-05485-x |
| spellingShingle | Jared Travers Mark Rochman Cora E. Miracle Jeff E. Habel Michael Brusilovsky Julie M. Caldwell Jeffrey K. Rymer Marc E. Rothenberg Chromatin regulates IL-33 release and extracellular cytokine activity Nature Communications |
| title | Chromatin regulates IL-33 release and extracellular cytokine activity |
| title_full | Chromatin regulates IL-33 release and extracellular cytokine activity |
| title_fullStr | Chromatin regulates IL-33 release and extracellular cytokine activity |
| title_full_unstemmed | Chromatin regulates IL-33 release and extracellular cytokine activity |
| title_short | Chromatin regulates IL-33 release and extracellular cytokine activity |
| title_sort | chromatin regulates il 33 release and extracellular cytokine activity |
| url | https://doi.org/10.1038/s41467-018-05485-x |
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