Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan
Dermatomyositis (DM) is a systemic autoimmune disease characterized by unique cutaneous manifestations and inflammatory myopathies. With the discovery of myositis-specific antibodies (MSAs), patients with DM, especially those with a higher risk of life-threatening complications, can be classified ac...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Dermatologica Sinica |
| Subjects: | |
| Online Access: | http://www.dermsinica.org/article.asp?issn=1027-8117;year=2023;volume=41;issue=1;spage=31;epage=35;aulast=Liu |
| _version_ | 1827945070318321664 |
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| author | Wei-Ting Liu Chao-Chun Yang |
| author_facet | Wei-Ting Liu Chao-Chun Yang |
| author_sort | Wei-Ting Liu |
| collection | DOAJ |
| description | Dermatomyositis (DM) is a systemic autoimmune disease characterized by unique cutaneous manifestations and inflammatory myopathies. With the discovery of myositis-specific antibodies (MSAs), patients with DM, especially those with a higher risk of life-threatening complications, can be classified according to the MSA type. This retrospective study aimed to investigate the clinical significance of MSAs in patients with DM in Taiwan. A total of 33 patients with DM who underwent the MSA test, including 26 with classic DM and 7 with amyopathic DM, were included. There were 13 men and 20 women, with a mean age at diagnosis of 49.6 years. MSA was detected in 26 (78.8%) of 33 patients with DM. The most frequently detected MSA was anti-melanoma differentiation-associated protein 5 (MDA5) (10/33, 30.3%) followed by anti-transcription intermediary factor-1γ (TIF-1γ) (8/33, 24.2%). Dysphagia was present in 6 (18.2%) of the 33 patients and more frequently developed in patients with anti-TIF-1γ (+) (5/8, 62.5%) than those with anti-TIF-1γ (−) (1/25, 4.0%). Interstitial lung disease was noted in 15 patients (45.5%) and developed more frequently in patients with anti-MDA5 (+) (7/10, 70.0%) than those with anti-MDA5 (−) (8/23, 34.8%). Malignancies were detected in 4 (12.1%) patients, with one each of anti-Mi-2 (+), anti-TIF-1γ (+), anti-ARS (+), and MSA (−). Mortality occurred in 6 (18.2%) patients, of whom 4 were anti-MDA5 (+). Anti-MDA5 and anti-TIF-1γ were the two most commonly detected MSAs. The presence of specific MSAs is associated with a certain phenotype, and integrating MSAs while evaluating DM aids in accurate patient management. |
| first_indexed | 2024-03-13T10:39:32Z |
| format | Article |
| id | doaj.art-eac4a73d5b6f48b4bef6eb94f999e94e |
| institution | Directory Open Access Journal |
| issn | 1027-8117 2223-330X |
| language | English |
| last_indexed | 2024-03-13T10:39:32Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj.art-eac4a73d5b6f48b4bef6eb94f999e94e2023-05-18T05:15:20ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172223-330X2023-01-01411313510.4103/ds.DS-D-22-00122Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in TaiwanWei-Ting LiuChao-Chun YangDermatomyositis (DM) is a systemic autoimmune disease characterized by unique cutaneous manifestations and inflammatory myopathies. With the discovery of myositis-specific antibodies (MSAs), patients with DM, especially those with a higher risk of life-threatening complications, can be classified according to the MSA type. This retrospective study aimed to investigate the clinical significance of MSAs in patients with DM in Taiwan. A total of 33 patients with DM who underwent the MSA test, including 26 with classic DM and 7 with amyopathic DM, were included. There were 13 men and 20 women, with a mean age at diagnosis of 49.6 years. MSA was detected in 26 (78.8%) of 33 patients with DM. The most frequently detected MSA was anti-melanoma differentiation-associated protein 5 (MDA5) (10/33, 30.3%) followed by anti-transcription intermediary factor-1γ (TIF-1γ) (8/33, 24.2%). Dysphagia was present in 6 (18.2%) of the 33 patients and more frequently developed in patients with anti-TIF-1γ (+) (5/8, 62.5%) than those with anti-TIF-1γ (−) (1/25, 4.0%). Interstitial lung disease was noted in 15 patients (45.5%) and developed more frequently in patients with anti-MDA5 (+) (7/10, 70.0%) than those with anti-MDA5 (−) (8/23, 34.8%). Malignancies were detected in 4 (12.1%) patients, with one each of anti-Mi-2 (+), anti-TIF-1γ (+), anti-ARS (+), and MSA (−). Mortality occurred in 6 (18.2%) patients, of whom 4 were anti-MDA5 (+). Anti-MDA5 and anti-TIF-1γ were the two most commonly detected MSAs. The presence of specific MSAs is associated with a certain phenotype, and integrating MSAs while evaluating DM aids in accurate patient management.http://www.dermsinica.org/article.asp?issn=1027-8117;year=2023;volume=41;issue=1;spage=31;epage=35;aulast=Liuanti-melanoma differentiation-associated protein 5 dermatomyositisanti-transcription intermediary factor-1γ dermatomyositisdysphagiainterstitial lung diseasemyositis-specific antibodies |
| spellingShingle | Wei-Ting Liu Chao-Chun Yang Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan Dermatologica Sinica anti-melanoma differentiation-associated protein 5 dermatomyositis anti-transcription intermediary factor-1γ dermatomyositis dysphagia interstitial lung disease myositis-specific antibodies |
| title | Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan |
| title_full | Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan |
| title_fullStr | Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan |
| title_full_unstemmed | Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan |
| title_short | Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan |
| title_sort | myositis specific antibodies in dermatomyositis a single center experience of 33 cases in taiwan |
| topic | anti-melanoma differentiation-associated protein 5 dermatomyositis anti-transcription intermediary factor-1γ dermatomyositis dysphagia interstitial lung disease myositis-specific antibodies |
| url | http://www.dermsinica.org/article.asp?issn=1027-8117;year=2023;volume=41;issue=1;spage=31;epage=35;aulast=Liu |
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